Dissecting PTEN-regulated pathways in the genesis of melanoma

剖析黑色素瘤发生过程中 PTEN 调控的通路

• 批准号: nhmrc : 1007706
• 负责人: Prof Helen Rizos
• 金额: $ 20.2万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-pten-regulated-genesis-melanoma/109243
• 关键词: Dissecting; PTEN; regulated; pathways; genesis

Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The PTEN phosphatase is one of the most common targets for inactivation in melanoma. The precise role of PTEN and its contribution to melanoma development have not been thoroughly explored. This work will highlight potentially novel pathways and molecules that are likely to be critical in the genesis of melanoma and to the rational approach to targeted therapy.

黑色素瘤是澳大利亚的一个主要健康问题。它是男性和女性中第三大常见癌症，对生命中的生产年产生不成比例的严重影响。PTEN磷酸酶是黑色素瘤中最常见的失活靶点之一。PTEN的确切作用及其对黑色素瘤发展的贡献尚未得到彻底研究。这项工作将突出潜在的新途径和分子，可能是关键的黑色素瘤的发生和合理的方法，以靶向治疗。