Manipulating oncogene addiction and immunity in the treatment of melanoma

在黑色素瘤的治疗中操纵癌基因成瘾和免疫

• 批准号: nhmrc : GNT1104503
• 负责人: Prof Helen Rizos
• 金额: $ 68.8万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/manipulating-oncogene-addiction-treatment-melanoma/1346364
• 关键词: Manipulating; oncogene; addiction; immunity; treatment

Melanoma is a major Australian health problem and a common cause of cancer death in young adults. Treatment of melanoma has been revolutionised in the last few years, but many patients fail to respond to new therapies or rapidly progress on treatment. This proposal examines the mechanisms that drive resistance to therapy and identifies markers predictive of clinical response. This approach will accelerate the development of new strategies and improve patient care by personalising treatment.

黑色素瘤是澳大利亚的一个主要健康问题，也是年轻人癌症死亡的常见原因。过去几年，黑色素瘤的治疗发生了革命性的变化，但许多患者未能对新疗法产生反应或治疗进展迅速。该提案研究了导致治疗耐药的机制，并确定了预测临床反应的标志物。这种方法将加速新策略的制定，并通过个性化治疗改善患者护理。