Manipulating oncogenic-signalling pathways in the genesis and treatment of melanoma

在黑色素瘤的发生和治疗中操纵致癌信号通路

• 批准号: nhmrc : 1003314
• 负责人: Prof Helen Rizos
• 金额: $ 40.11万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/manipulating-oncogenic-signalling-treatment-melanoma/108915
• 关键词: Manipulating; oncogenic; signalling; pathways; genesis

Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The use of small molecule inhibitors is the most promising strategy for treating melanoma. In this project, we will examine the mechanisms of resistance to this class of drugs and define new drug targets by examining the molecular-circuitry is damaged in melanomas. This work will greatly accelerate the development of new therapies.

黑色素瘤是澳大利亚的一个主要健康问题。它是男性和女性中第三大常见癌症，对生命中的生产年产生不成比例的严重影响。使用小分子抑制剂是治疗黑色素瘤最有前途的策略。在本项目中，我们将研究对此类药物的耐药性机制，并通过研究黑色素瘤中分子电路的受损来定义新的药物靶点。这项工作将大大加速新疗法的开发。