MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 6743200
• 负责人: CHARLES RICHARD ROSENFELD
• 金额: $ 48.46万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743200
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

This proposal is a reapplication from The University of Texas Southwestern Medical Center at Dallas to participate in the Cooperative Multicenter Neonatal Research Network (RFA: HD-00-010). Abbot R. Laptook, M.D. will serve as the Principal Investigator and the Alternate will be Walid A. Salhab, M.D. The primary teaching hospital of the UT Southwestern Medical Center is Parkland Hospital, which has the largest delivery population of any hospital in the United States. The Neonatal Intensive Care Unit (NICU) at Parkland has a bed capacity of 100 and is a state of the art facility. Adjoining Parkland Hospital is Children's Medical Center, which provides all needed specialized pediatric services for radiologic, operative, and cardiac procedures. There are a number of considerations that justify UT Southwestern continuing as one of the sites for the Network. First, a large inborn population is provided, and in spite of changes in health care delivery, Parkland Health and Hospital System has been able to maintain their delivery population, and admissions to the NICU have been relatively constant over the past decade. This reflects a well organized institutional approach to providing health care, and an established Obstetric service which is integrated within the health care delivery services of targeted communities of Dallas. Second, the UT Southwestern site offers ethnic diversity for the Network by providing a large number of Hispanic patients. Currently, the delivery population is 77% Hispanic and admissions to the NICU are 64% Hispanic. Third, the UT Southwestern site has a proven track record within the Network. It has been a member institution since the inception of the Network and continues to have a well organized system with a high percent of eligible infants enrolled in randomized trials, limited errors in conducting studies, complete data acquisition, and an almost 90% follow-up rate. Fourth, the PI provides expertise in cerebral metabolism and blood flow which will benefit the design and implementation of studies directed at perinatal brain damage. Finally, the Division of Neonatal-Perinatal Medicine at UT Southwestern has a strong commitment to clinical research and maintains a clinical management approach, which is reluctant to adopt new therapies without sufficient evaluation and evidence.

该提案是达拉斯德克萨斯大学西南医学中心参与多中心新生儿合作研究网络（RFA：HD-00-010）的重新申请。 Abbot R. Laptook 医学博士将担任首席研究员，候补研究员为 Walid A. Salhab 医学博士。 UT 西南医学中心的主要教学医院是 Parkland 医院，该医院是美国分娩人数最多的医院。 Parkland 的新生儿重症监护病房 (NICU) 可容纳 100 张床位，设施先进。毗邻帕克兰医院的是儿童医疗中心，该中心为放射学、手术和心脏手术提供所有所需的专业儿科服务。出于多种考虑因素，德州大学西南航空学院继续作为该网络的站点之一是合理的。首先，提供了大量的出生人口，尽管医疗保健服务发生了变化，帕克兰健康和医院系统仍然能够维持其出生人口，并且在过去十年中新生儿重症监护病房的入院率相对稳定。这反映了提供医疗保健的组织良好的机构方法，以及整合到达拉斯目标社区的医疗保健提供服务中的成熟产科服务。其次，UT 西南站点通过提供大量西班牙裔患者来为网络提供种族多样性。目前，分娩人口中有 77% 是西班牙裔，新生儿重症监护病房 (NICU) 入住的人数中有 64% 是西班牙裔。第三，UT Southwestern 站点在网络中拥有良好的记录。自该网络成立以来，它一直是一个成员机构，并继续拥有一个组织良好的系统，符合条件的婴儿参加随机试验的比例很高，进行研究的错误有限，数据采集完整，随访率接近 90%。第四，PI提供脑代谢和血流方面的专业知识，这将有利于针对围产期脑损伤的研究的设计和实施。最后，德克萨斯大学西南医学中心的新生儿-围产期医学部门坚定地致力于临床研究，并维持临床管理方法，在没有充分评估和证据的情况下不愿采用新疗法。