MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 6895903
• 负责人: CHARLES RICHARD ROSENFELD
• 金额: $ 81.78万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6895903
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

This proposal is a reapplication from The University of Texas Southwestern Medical Center at Dallas to participate in the Cooperative Multicenter Neonatal Research Network (RFA: HD-00-010). Abbot R. Laptook, M.D. will serve as the Principal Investigator and the Alternate will be Walid A. Salhab, M.D. The primary teaching hospital of the UT Southwestern Medical Center is Parkland Hospital, which has the largest delivery population of any hospital in the United States. The Neonatal Intensive Care Unit (NICU) at Parkland has a bed capacity of 100 and is a state of the art facility. Adjoining Parkland Hospital is Children's Medical Center, which provides all needed specialized pediatric services for radiologic, operative, and cardiac procedures. There are a number of considerations that justify UT Southwestern continuing as one of the sites for the Network. First, a large inborn population is provided, and in spite of changes in health care delivery, Parkland Health and Hospital System has been able to maintain their delivery population, and admissions to the NICU have been relatively constant over the past decade. This reflects a well organized institutional approach to providing health care, and an established Obstetric service which is integrated within the health care delivery services of targeted communities of Dallas. Second, the UT Southwestern site offers ethnic diversity for the Network by providing a large number of Hispanic patients. Currently, the delivery population is 77% Hispanic and admissions to the NICU are 64% Hispanic. Third, the UT Southwestern site has a proven track record within the Network. It has been a member institution since the inception of the Network and continues to have a well organized system with a high percent of eligible infants enrolled in randomized trials, limited errors in conducting studies, complete data acquisition, and an almost 90% follow-up rate. Fourth, the PI provides expertise in cerebral metabolism and blood flow which will benefit the design and implementation of studies directed at perinatal brain damage. Finally, the Division of Neonatal-Perinatal Medicine at UT Southwestern has a strong commitment to clinical research and maintains a clinical management approach, which is reluctant to adopt new therapies without sufficient evaluation and evidence.

本提案是位于达拉斯的德克萨斯大学西南医学中心再次申请参加合作多中心新生儿研究网络（RFA：HD-00-010）。阿伯特河Laptook，医学博士将担任主要研究者，候补研究者为Walid A。Salhab医学博士UT西南医学中心的主要教学医院是帕克兰医院，它是美国所有医院中分娩人数最多的医院。帕克兰的新生儿重症监护室有100张床位，是最先进的设施。毗邻帕克兰医院的是儿童医疗中心，它提供所有需要的专门儿科服务的放射，手术和心脏手术。有一些考虑因素证明UT西南继续作为网络的网站之一。首先，提供了大量的先天性人口，尽管卫生保健服务发生了变化，但帕克兰卫生和医院系统一直能够维持其分娩人口，在过去十年中，新生儿重症监护室的入院人数相对稳定。这反映了一个组织良好的机构提供保健的方法，以及一个既定的产科服务，这是整合在达拉斯的目标社区的保健提供服务。其次，UT西南网站提供了大量的西班牙裔患者，为网络提供了种族多样性。目前，分娩人口中有77%是西班牙裔，新生儿重症监护病房的入院人数中有64%是西班牙裔。第三，UT西南网站在网络中有着良好的记录。自该网络成立以来，它一直是该网络的成员机构，并继续拥有组织良好的系统，有很高比例的合格婴儿参加随机试验，进行研究时的错误有限，数据采集完整，随访率接近90%。第四，PI提供脑代谢和血流方面的专业知识，这将有利于设计和实施针对围产期脑损伤的研究。最后，UT西南部的新生儿-围产期医学部对临床研究有着坚定的承诺，并保持着一种临床管理方法，在没有足够的评估和证据的情况下，不愿意采用新的疗法。