MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

母胎医学单位的多中心网络

• 批准号: 6746926
• 负责人: Anthony Sciscione
• 金额: $ 76.65万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6746926
• 关键词: ampicillin; antibiotics; chemoprevention; clinical trials; combination chemotherapy; cooperative study; embryo /fetus membrane; epidemiology; erythromycin; female; glucocorticoids; human pregnant subject; human subject; human therapy evaluation; information systems; medical outreach /case finding; molecular genetics; mother /infant health care; neonatal intensive care; patient oriented research; perinatal; pregnancy disorder chemotherapy; pregnancy immunology; pregnancy infection; premature infant human; premature labor; prenatal care; steroid hormone; ultrasonography; women' s health

DESCRIPTION (provided by applicant): Jefferson Medical College is submitting a competing renewal to the "Cooperative Multicenter Maternal-Fetal Medicine Units Network. Jefferson has been an active and productive participant in the Maternal-Fetal Medicine Units (MFMU) Network over the last four years. The Jefferson Center (JC) has actively recruited for all MFMU protocols and has routinely been among the top centers in patient recruitment, data accuracy, and data reliability. The JC PI is chairman of both the steroid and the genetics subcommittees. JC faculty and staff has partipated on subcommittees, introduced concepts, participated in Steering Committee meetings, and performed secondary analysis of data. The JC provides the Network with over 8,700 deliveries per year of which over 35% are high-risk. All patients are available to participate in trials. The JC has a faculty of 20 Maternal-Fetal Medicine subspecialists with 6 designated physicians having primary responsibility for Network activity. These physicians have adequate protected time. Jefferson has an academic research environment demonstrated by its Network participation to date, participation in other multicenter trials, and existence of an extensive research infrastructure. There are intrapartum and antepartum facilities for research recruitment, hospital staffs experienced in research participation, and a large research staff (nurse coordinator, 3 masters nurses, 6 RNs, 2 research associates, a full-time data base manager and a data entry clerk). The JC has a large academic neonatal service with 1,874 neonates cared for per year by 23 full-time neonatologists. The neonatal unit is submitting an application for participation in the Neonatal Intensive Care Unit (NICU) Network. The JC offers the Network additional expertise in clinical and molecular genetics, ultrasound, and epidemiology. Administrative strength include a large organized perinatal network (>30,000 births per year) providing additional patients when required. The JC has proposed a concept on the timing of cervical cerclage removal following preterm premature rupture of membranes. The supporting documentation for this prospective randomized trial demonstrates the Center?s research acumen as well as the breath and strength of the data base. The JC is strongly committed and prepared to continue active participation in the MFMU.

描述（由申请人提供）：杰斐逊医学院正在提交 多中心母婴医学合作组织（Cooperative Multicenter Maternal-Fetal Medicine） 单位网络。杰斐逊一直是一个积极和富有成效的 在过去的一年里， 四年杰斐逊中心（JC）积极招募所有MFMU 协议，并已例行的顶级中心在患者招募， 数据的准确性和可靠性。JC PI是两个组织的主席， 类固醇和遗传学小组委员会JC的教职员工已经在 小组委员会，介绍概念，参加指导委员会 会议，并对数据进行了二次分析。JC提供了 每年有超过8，700次交付，其中超过35%是高风险的。 所有患者均可参加试验。JC有一个教师， 20名母胎医学专科医生，6名指定医生， 主要负责网络活动。这些医生有足够的 保护时间杰斐逊有一个学术研究环境证明， 其迄今为止的网络参与，参与其他多中心试验， 和广泛的研究基础设施的存在。有产时 和产前设施的研究招聘，医院工作人员 有丰富的参与研究的经验，以及大量的研究人员（护士 协调员，3名硕士护士，6名注册护士，2名研究助理，1名全职数据 基地管理员和数据录入员）。JC拥有大量学术新生儿 每年有23名全职产科医生为1 874名新生儿提供护理服务。 新生儿科正在提交参加 新生儿重症监护室网络。JC提供网络 在临床和分子遗传学，超声，和 流行病学行政力量包括一个大的有组织的围产期 网络（每年超过30，000例分娩），在需要时提供额外的病人。 JC提出了一个关于宫颈环扎术取出时间的概念 早产儿胎膜早破支撑 这项前瞻性随机试验的文件证明，该中心？S 研究的敏锐性以及数据库的气息和力量。JC是 坚定承诺并准备继续积极参与MFMU。