MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

母胎医学单位的多中心网络

• 批准号: 6899726
• 负责人: Anthony Sciscione
• 金额: $ 65.66万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6899726
• 关键词: ampicillin; antibiotics; chemoprevention; clinical trials; combination chemotherapy; cooperative study; embryo /fetus membrane; epidemiology; erythromycin; female; glucocorticoids; human pregnant subject; human subject; human therapy evaluation; information systems; medical outreach /case finding; molecular genetics; mother /infant health care; neonatal intensive care; patient oriented research; perinatal; pregnancy disorder chemotherapy; pregnancy immunology; pregnancy infection; premature infant human; premature labor; prenatal care; steroid hormone; ultrasonography; women' s health

DESCRIPTION (provided by applicant): Jefferson Medical College is submitting a competing renewal to the "Cooperative Multicenter Maternal-Fetal Medicine Units Network. Jefferson has been an active and productive participant in the Maternal-Fetal Medicine Units (MFMU) Network over the last four years. The Jefferson Center (JC) has actively recruited for all MFMU protocols and has routinely been among the top centers in patient recruitment, data accuracy, and data reliability. The JC PI is chairman of both the steroid and the genetics subcommittees. JC faculty and staff has partipated on subcommittees, introduced concepts, participated in Steering Committee meetings, and performed secondary analysis of data. The JC provides the Network with over 8,700 deliveries per year of which over 35% are high-risk. All patients are available to participate in trials. The JC has a faculty of 20 Maternal-Fetal Medicine subspecialists with 6 designated physicians having primary responsibility for Network activity. These physicians have adequate protected time. Jefferson has an academic research environment demonstrated by its Network participation to date, participation in other multicenter trials, and existence of an extensive research infrastructure. There are intrapartum and antepartum facilities for research recruitment, hospital staffs experienced in research participation, and a large research staff (nurse coordinator, 3 masters nurses, 6 RNs, 2 research associates, a full-time data base manager and a data entry clerk). The JC has a large academic neonatal service with 1,874 neonates cared for per year by 23 full-time neonatologists. The neonatal unit is submitting an application for participation in the Neonatal Intensive Care Unit (NICU) Network. The JC offers the Network additional expertise in clinical and molecular genetics, ultrasound, and epidemiology. Administrative strength include a large organized perinatal network (>30,000 births per year) providing additional patients when required. The JC has proposed a concept on the timing of cervical cerclage removal following preterm premature rupture of membranes. The supporting documentation for this prospective randomized trial demonstrates the Center?s research acumen as well as the breath and strength of the data base. The JC is strongly committed and prepared to continue active participation in the MFMU.

描述（由申请人提供）：杰佛逊医学院申请