MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

母胎医学单位的多中心网络

• 批准号: 6608160
• 负责人: Anthony Sciscione
• 金额: $ 95.86万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608160
• 关键词: ampicillin; antibiotics; chemoprevention; clinical trials; combination chemotherapy; cooperative study; embryo /fetus membrane; epidemiology; erythromycin; female; glucocorticoids; human pregnant subject; human subject; human therapy evaluation; information systems; medical outreach /case finding; molecular genetics; mother /infant health care; neonatal intensive care; patient oriented research; perinatal; pregnancy disorder chemotherapy; pregnancy immunology; pregnancy infection; premature infant human; premature labor; prenatal care; steroid hormone; ultrasonography; women's health

DESCRIPTION (provided by applicant): Jefferson Medical College is submitting a competing renewal to the "Cooperative Multicenter Maternal-Fetal Medicine Units Network. Jefferson has been an active and productive participant in the Maternal-Fetal Medicine Units (MFMU) Network over the last four years. The Jefferson Center (JC) has actively recruited for all MFMU protocols and has routinely been among the top centers in patient recruitment, data accuracy, and data reliability. The JC PI is chairman of both the steroid and the genetics subcommittees. JC faculty and staff has partipated on subcommittees, introduced concepts, participated in Steering Committee meetings, and performed secondary analysis of data. The JC provides the Network with over 8,700 deliveries per year of which over 35% are high-risk. All patients are available to participate in trials. The JC has a faculty of 20 Maternal-Fetal Medicine subspecialists with 6 designated physicians having primary responsibility for Network activity. These physicians have adequate protected time. Jefferson has an academic research environment demonstrated by its Network participation to date, participation in other multicenter trials, and existence of an extensive research infrastructure. There are intrapartum and antepartum facilities for research recruitment, hospital staffs experienced in research participation, and a large research staff (nurse coordinator, 3 masters nurses, 6 RNs, 2 research associates, a full-time data base manager and a data entry clerk). The JC has a large academic neonatal service with 1,874 neonates cared for per year by 23 full-time neonatologists. The neonatal unit is submitting an application for participation in the Neonatal Intensive Care Unit (NICU) Network. The JC offers the Network additional expertise in clinical and molecular genetics, ultrasound, and epidemiology. Administrative strength include a large organized perinatal network (>30,000 births per year) providing additional patients when required. The JC has proposed a concept on the timing of cervical cerclage removal following preterm premature rupture of membranes. The supporting documentation for this prospective randomized trial demonstrates the Center?s research acumen as well as the breath and strength of the data base. The JC is strongly committed and prepared to continue active participation in the MFMU.

描述(由申请者提供)：杰斐逊医学院提交 “多中心合作母婴医学”的竞争性更新 单位网络。杰斐逊一直是一个积极和富有成效的 过去参与母婴医学部(MFMU)网络 四年了。杰斐逊中心(JC)已为所有MFMU积极招聘 协议，并一直是顶级的患者招募中心之一， 数据准确性和数据可靠性。JC Pi是这两家公司的主席 类固醇和遗传学小组委员会。JC教职员工参与了 小组委员会，介绍概念，参加指导委员会 会议，并对数据进行二次分析。JC提供了 每年超过8,700次递送的网络，其中超过35%是高风险的。 所有患者都可以参加试验。JC拥有一支 20名母婴医学专科医生和6名指定医生 网络活动的主要责任。这些医生有足够的 受保护的时间。杰斐逊有一个学术研究环境，由 其迄今的网络参与、参与其他多中心试验、 以及广泛的研究基础设施的存在。有产时有 以及为科研招聘、医院工作人员提供的产前设施 有参与研究的经验，有大量的研究人员(护士 协调员，3名护士长，6名注册护士，2名研究助理，1名全职数据 基地经理和数据录入员)。JC有一个庞大的学术新生 每年为1874名新生儿提供服务，由23名全职新生儿医生护理。 新生儿病房正在提交申请，要求参加 新生儿重症监护病房(NICU)网络。JC提供网络 在临床和分子遗传学、超声波和 流行病学。管理力量包括有组织的大型围产期 网络(每年30,000名新生儿)在需要时提供额外的病人。 JC提出了一个关于宫颈环扎术时间的概念 在早产胎膜早破之后。支持 这项前瞻性随机试验的文献证明了中心？S 研究的敏锐性以及数据库的气息和实力。JC是 坚定承诺并准备继续积极参加最惠国集团。