Nanoliter Tear Osmometer for the Detection of Dry Eye

用于检测干眼症的纳升泪液渗透压计

• 批准号: 6834523
• 负责人: GREGORY BENNETT MD
• 金额: $ 11.54万
• 依托单位: OPTICOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834523
• 关键词: biomedical equipment development; biosensor device; charge coupled device camera; clinical biomedical equipment; clinical chemistry; clinical research; computer system design /evaluation; diagnosis design /evaluation; eye disorder diagnosis; human subject; image processing; keratoconjunctivitis sicca; measurement; osmotic pressure; tear

This research intends to develop a Nanoliter Tear Osmometer for the detection of the presence and degree of dry eye. It is estimated that 40-60 million Americans have dry eye symptoms. Prescription pharmaceuticals are appearing on the market to treat dry eye yet methods for diagnosis and monitoring treatment remain problematic. This Phase I research will make use of a new technology for analyzing tear osmolarity, which is popularly accepted by experts in the field as an indicator of the occurrence and severity of dry eye. Specifically, the research will develop an instrument to analyze nanoliter volumes of tears that offers quick, reliable, and an accurate measure of osmolarity. It is the intention of research team to develop a system that is simple to use and requires no special training thereby making it a suitable device for the clinical ophthalmologist or optometrist. The technological approach proposed is unique and innovative, as it overcomes many of the shortcomings of conventional osmolarity measurements. Commercial potential for such a device is high, since it is projected that cost in production will be in-line with other instruments purchased by clinicians. The pharmaceutical industry has invested large dollar amounts into treatment of dry eye and expect large returns in the next several years. With this introduciton of prescription treatment of dry eye it may become a necessity to have proper a diagnostic tool, and the osmometer proposed has attributes ideally suited for clinical examinations. The use of existing proven technology and applying it to tear osmolarity forms the basis of this Phase I research. Several factors on the effectiveness of measuring tear osmolarity will be examined, including resolution, sensitivity, and overall performance. The research will conclude with an IRB approved study.

这项研究旨在开发纳米质撕裂渗透压计，以检测干眼症的存在和程度。据估计，有40-6000万美国人患有干眼症状。处方药出现在市场上，以治疗干眼症，但诊断和监测治疗方法仍然有问题。这一I阶段研究将利用一种新技术来分析撕裂渗透压，该技术被该领域的专家普遍接受，以表明干眼症的发生和严重程度。具体而言，这项研究将开发一种仪器来分析纳米素的泪水量，可提供快速，可靠和准确的渗透压度量。研究团队的目的是开发一种易于使用的系统，并且不需要特殊培训，从而使其成为适合该系统的设备 临床眼科医生或验光师。提出的技术方法是独特而创新的，因为它克服了常规渗透压测量的许多缺点。这种设备的商业潜力很高，因为预计生产成本将与临床医生购买的其他工具一致。制药行业已经投入了大量美元来治疗干眼症，并预计未来几年的回报率很高。通过这种干眼处处方处理的介绍，可能有必要 适当的诊断工具和提议的操作计具有理想适合临床检查的属性。现有经过验证的技术的使用并将其应用于撕裂渗透压构成了本阶段研究的基础。将检查有关测量撕裂渗透压的有效性的几个因素，包括分辨率，灵敏度和整体性能。该研究将以IRB认可的研究结束。