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High throughput genetic approaches to identify targets for new antimalarial drugs / From Anticancer to Antimalarial Agent: Repositioning Quarfloxin

高通量遗传学方法来确定新抗疟药物的靶点/从抗癌到抗疟药物：重新定位夸氟辛

基本信息

批准号：
2302748
负责人：
金额：
--
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2302748
关键词：
throughput genetic approaches identify targets

项目摘要

I am applying to the aforementioned projects because I am passionately interested in the study of infectious disease. I have an extensive theoretical and practical background in parasitology, particularly the study of the neglected tropical diseases leishmaniasis and trypanosomiasis and this has imbued in me the desire to pursue a research career in this field. I am further intrigued by the translational aspect of the study of parasitic infections, primarily how new therapies can be discovered, designed and implemented to reduce disease burden worldwide. I am keen to participate in research at the precipice of drug discovery and therapeutic development in infectious disease and I am acutely aware of the significance of the Malaria-causing Plasmodium species as significant contributors to morbidity and mortality in the developing world. I am excited by the projects offered concerning these themes and I am aspiring to forge my research career in the esteemed labs and institutes hosting the projects. I would relish the opportunity to work under excellent researchers such as Dr Julian Rayner and Dr Catherine Merrick because they are conducting outstanding and impactful research and are endeavoring to make a tangible impact in Plasmodium science and I believe undertaking my PhD project with their guidance and tutelage would permit me make my own telling contribution to the field.

我申请上述项目是因为我对传染病的研究非常感兴趣。我在寄生虫学方面有广泛的理论和实践背景，特别是对被忽视的热带疾病利什曼病和锥虫病的研究，这使我渴望在这一领域从事研究工作。我对寄生虫感染研究的转化方面更感兴趣，主要是如何发现，设计和实施新疗法以减少全球疾病负担。我热衷于参与研究在药物发现和治疗发展的悬崖上的传染病，我敏锐地意识到疟疾引起的疟原虫物种的重要性，作为发展中国家发病率和死亡率的重要贡献者。我对这些主题所提供的项目感到兴奋，我渴望在主持这些项目的受人尊敬的实验室和研究所中建立我的研究生涯。我会很高兴有机会在优秀的研究人员，如朱利安·雷纳博士和凯瑟琳博士梅里克工作，因为他们正在进行杰出的和有影响力的研究，并正在努力使疟原虫科学的切实影响，我相信在他们的指导和监护下进行我的博士项目将允许我作出自己的贡献告诉该领域。