A novel recombinant vaccine against Cryptococcus.
A novel recombinant vaccine against Cryptococcus.
批准号:
6841870
负责人:
Claude P Selitrennikoff
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-07-01 至 2006-06-30
中文摘要
描述(由申请人提供):新型隐球菌是一种包膜致病性酵母菌,可引起人类和其他动物肺部感染和脑膜脑炎。在过去20年中,世界各地隐球菌病的发病率急剧增加,这不仅反映了艾滋病毒感染的增加,而且反映了免疫功能受损患者人数的增加。CD4+ T细胞的缺失使患者易发生新形梭菌的进行性感染——这强调了细胞介导的免疫在宿主抵抗中的作用。
英文摘要
DESCRIPTION (provided by applicant): Cryptococcus neoformans is an encapsulated pathogenic yeast that causes pulmonary infections and meningoencephalitis in humans and other animals. During the last 20 years, there has been a dramatic increase in the incidence of cryptococcosis throughout the world that mirrors the increase in not only HIV infections, but also in the growing number of immuno compromised patients. Loss of CD4+ T cells predisposes patients to progressive infection with C. neoformans--this emphasizes the role of cell mediated immunity in host resistance.
Our long-term corporate goals are to discover new drugs for the treatment of fungal diseases and to develop vaccines against a number of human pathogenic fungi. In this Phase I STTR proposal, we plan to develop a safe and effective vaccine against C. neoformans. We will use a novel antigen delivery system and test a number of C. neoformans proteins as vaccine candidates. We will accomplish this in two specific aims:
Specific Aim One: Engineer yeast cells to express each of five C. neoformans proteins using recombinant DNA technology.
Specific Aim Two: Test the in vivo efficacy of each vaccine formulation to protect vaccinated animals against a challenge of C. neoformans.
This work will be a prelude to work in Phase II that will include detailed testing for in vivo efficacy and safety of each vaccine candidate. Ultimately, the Phase I, Phase II and Phase lll research will lead to the development of a vaccine against C. neoformans
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Leishmania major nucleoside hydrolase inhibitors
-
批准号:7269652
-
项目类别:
-
资助金额:$10.2万
-
财政年份:2007
-
负责人:Claude P Selitrennikoff
-
依托单位:
A novel vaccine against Leishmania
-
批准号:6932638
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2005
-
负责人:Claude P Selitrennikoff
-
依托单位:
New drugs for the treatment of leishmaniasis
-
批准号:6832750
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2004
-
负责人:Claude P Selitrennikoff
-
依托单位:
How is Cryptococcus resistant ot echinocandins?
-
批准号:6746506
-
项目类别:
-
资助金额:$18.22万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
A novel yeast vaccine against Coccidioides Immitis
-
批准号:6645740
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
The glyoxylate cycle as a new target for antifungals
-
批准号:6579674
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
Inhibitors of transcription of fungal glucan synthase
-
批准号:6688368
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
Antifungal drugs: Beta(1,6)-glucan synthesis inhibitors
-
批准号:6643954
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
How is Cryptococcus resistant ot echinocandins?
-
批准号:6802271
-
项目类别:
-
资助金额:$17.57万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
A novel vaccine for Aspergillus fumigatus
-
批准号:6693955
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2003
-
负责人:Claude P Selitrennikoff
-
依托单位:
A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORING
-
批准号:6442431
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2002
-
负责人:Claude P Selitrennikoff
-
依托单位:
A NOVEL ANTIFUNGAL COMPOUND FROM CAYENNE PEPPER
-
批准号:6292083
-
项目类别:
-
资助金额:$9.96万
-
财政年份:2001
-
负责人:Claude P Selitrennikoff
-
依托单位:
EVALUATION OF ZEAMATIN AS AN ANTIFUNGAL THERAPEUTIC
-
批准号:2522136
-
项目类别:
-
资助金额:$8.29万
-
财政年份:1998
-
负责人:Claude P Selitrennikoff
-
依托单位:
SCREENING OF THERMOPHILES FOR ANTIFUNGAL ACTIVITY
-
批准号:6016838
-
项目类别:
-
资助金额:$42.2万
-
财政年份:1997
-
负责人:Claude P Selitrennikoff
-
依托单位:
ZEAMATIN, AN ANTIFUNGAL THERAPEUTIC
-
批准号:2660429
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1997
-
负责人:Claude P Selitrennikoff
-
依托单位:
SCREENING OF THERMOPHILES FOR ANTIFUNGAL ACTIVITY
-
批准号:6169789
-
项目类别:
-
资助金额:$32.44万
-
财政年份:1997
-
负责人:Claude P Selitrennikoff
-
依托单位:
NOVEL ANTIFUNGAL SCREEN--CELL WALL REGULATION INHIBITORS
-
批准号:2660428
-
项目类别:
-
资助金额:$9.94万
-
财政年份:1997
-
负责人:Claude P Selitrennikoff
-
依托单位:
SCREENING OF THERMOPHILES FOR ANTIFUNGAL ACTIVITY
-
批准号:2417531
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1997
-
负责人:Claude P Selitrennikoff
-
依托单位:
SCREEN FOR FUNGAL KETOL/ISOMERASE INHIBITORS
-
批准号:2075767
-
项目类别:
-
资助金额:$9.64万
-
财政年份:1996
-
负责人:Claude P Selitrennikoff
-
依托单位:
SCREENING OF MARINE ORGANISMS FOR ANTIFUNGAL ACTIVITY
-
批准号:2005272
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1996
-
负责人:Claude P Selitrennikoff
-
依托单位:
国内基金
海外基金
登录
查看更多内容
基于菌体蛋白泄漏探究超高压对酿酒酵母Saccharomyces cerevisiae烯醇化酶致敏性的影响
-
批准号:--
-
项目类别:面上项目
-
资助金额:59万元
-
批准年份:2021
-
负责人:孙爱东
-
依托单位:
Saccharomyces cerevisiae NJWGYH30566产赤藓糖醇的辅酶工程及调控机理
-
批准号:31171644
-
项目类别:面上项目
-
资助金额:64.0万元
-
批准年份:2011
-
负责人:胡永红
-
依托单位:
3-甲硫基丙醇的Saccharomyces cerevisiae关键代谢分子调控机制研究
-
批准号:31071593
-
项目类别:面上项目
-
资助金额:36.0万元
-
批准年份:2010
-
负责人:王成涛
-
依托单位:
新疆慕萨莱思Saccharomyces cerevisiae发酵特性研究
-
批准号:31060223
-
项目类别:地区科学基金项目
-
资助金额:27.0万元
-
批准年份:2010
-
负责人:朱丽霞
-
依托单位: