A Twin Study of Chronic Fatigue Syndrome in Sweden

瑞典慢性疲劳综合症的双胞胎研究

基本信息

批准号：
6642831
负责人：
NANCY L PEDERSEN
金额：
$ 14.98万
依托单位：
KAROLINSKA INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-08-15 至 2006-01-31
项目状态：
已结题

项目摘要

Despite considerable research, fundamental questions about CFS remain at best partially answered. These questions include its definition, validity, the degree to which it results from genetic versus environmental factors, the nature of the substantial comorbidity observed with other conditions, and the basis of the female preponderance. The overarching aim of this project is to shed light on a number of basic questions about CFS via a large, population-based classical twin study. First, we will collect data on approximately 32,000 adults aged 42-65 years (13,000 complete twin pairs) who are members of the population- based Swedish Twin Registry for persistent fatigue, several overlapping conditions (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression), and a detailed medical history. Second, the medical records of all twins who appear to have CFS-like illness and a subset of those with "CFS-explained" will be requested via an efficient national retrieval system. Following expert review, these individuals will be classified in regard to the CDC CFS criteria. Obtaining these unique data will allow us to address a set of critical questions regarding CFS. First, we will estimate the prevalence of CFS and its common comorbidities (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression) in one of the largest samples yet studied. Second, we will use a variety of multivariate techniques to derive an empirical typology of prolonged fatigue and to assess how this typology compares to the CFS definition. Third, we will quantify the genetic and environmental sources of variation for CFS and its comorbid conditions. Fourth, critically, we will examine the influence of gender on these sources of variation. Finally, we will analyze the patterns of comorbidity between CFS and fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression using multivariate twin analyses and thereby to estimate the extent of overlap between the shared and unique genetic and environmental sources of variation. In concert with other twin studies being conducted by the investigators and their collaborators, we hope to hasten progress in understanding the etiology of CFS by parallel studies in multiple populations. The current proposal has several unique aims and represents a cost-effective means to extend this work in an epidemiological sample that is arguably the best twin registry in the world.

尽管进行了大量研究，但有关CFS的基本问题仍然得到了部分答案。这些问题包括其定义，有效性，遗传因素与环境因素的程度，与其他条件下观察到的实质合并症的性质以及女性优势的基础。该项目的总体目的是通过一项基于人群的大型古典双胞胎研究阐明有关CFS的许多基本问题。首先，我们将收集有关大约32,000名42-65岁（13,000个完整双胞胎）的成年人的数据，他们是基于人口的瑞典双胞胎持续疲劳注册表的成员，几种重叠的状况（纤维肌痛，肠胃痛，肠综合征，紧张头痛，急诊/exemagy/exezema，Ellergy/execema，extresergy/exegema，exlergy/exemperized焦虑症和重大抑郁症和重大抑郁症和重大抑郁症和详细疾病），并有一个细节。其次，将通过有效的国家检索系统要求所有似乎患有CFS样疾病的双胞胎的病历以及具有“ CFS解释”的人的一部分。经过专家审查，这些人将根据CDC CFS标准进行分类。获得这些独特的数据将使我们能够解决有关CFS的一系列关键问题。首先，我们将估计CFS及其常见合并症的患病率（纤维肌痛，肠易激综合征，张力头痛，过敏/湿疹，广义焦虑症和重大抑郁症）在尚未研究的最大样本中之一。其次，我们将使用各种多元技术来得出长期疲劳的经验类型，并评估该类型学与CFS定义的比较。第三，我们将量化CFS及其合并症变异的遗传和环境源。第四，至关重要的是，我们将研究性别对这些变异来源的影响。最后，我们将使用多变量双胞胎分析分析CFS和纤维肌痛，肠易激综合症，张力头痛，过敏/湿疹，广泛性焦虑症和重度抑郁症之间合并症的模式，从而估算共享和独特的遗传和环境之间的重叠程度。与研究人员及其合作者进行的其他双胞胎研究一致，我们希望通过在多个人群中的并行研究来加快理解CFS病因的进展。当前的提案具有几个独特的目标，并且代表了一种经济高效的手段，可以在流行病学样本中扩展这项工作，这可以说是世界上最好的双胞胎注册表。