Environmental Factors for Parkinson's in Swedish Twins

瑞典双胞胎帕金森病的环境因素

基本信息

批准号：
6739107
负责人：
NANCY L PEDERSEN
金额：
$ 26.52万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-05-01 至 2006-04-30
项目状态：
已结题

项目摘要

The primary purpose of the proposed research is to assess the importance of environmental factors for Parkinson's Disease (PD) in a population-based sample of Swedish Twins. All twins 55 years of age and older in the Swedish Twin Registry are currently undergoing computer assisted telephone interviews to screen for most common, complex diseases, including PD, dementia, and depression. We have already screened 22,788 individuals and know how many screen positive for Parkinson's symptoms. On this basis we project that, from the 26,000 individuals who will be interviewed by September 2000, nearly 1100 individuals will screen positive for PD. A physician will examine all potential cases and their co-twins for establishing clinical diagnosis. Medical records will be obtained for all hospital admissions as well as from primary health care facilities. Once sufficient cases have been seen, clinical diagnoses will be used to evaluate sensitivity and specificity of the screening procedure, and algorithms for identifying positive screens will be adjusted. Blood samples will be obtained for purposes of zygosity confirmation and molecular work. The main methodological approach to studying environmental factors will be through the use of discordant pairs. There will be approximately 580 twin pairs, in which both are alive, discordant for a positive screen. Information about environmental exposures will be secured with a computer assisted survey by a third party blind to diagnosis. In addition, most twins responded 28 years ago to a questionnaire concerning exposures (occupation, education, residential history, health status, smoking, diet, environmental irritants, etc.). Matched-pair "co-twin control" analyses as well as quantitative genetic approaches will address the following questions: 1) In PD discordant twin pairs, what are the environmental risk factors that contribute to the disease in the affected twin and or protect the unaffected twin? What are the long-term influences of exposures reported 28 years ago and prior to onset of the disease? Are there sex differences in the importance of these exposures? 2) Are earlier reports of low heritability reported for elderly male-male twins by Tanner and colleagues confirmed for female-female and unlike-sexed pairs? 3) Is the relative importance of genetic and shared familial environmental influences different for early than for late onset PD? Are influences on age at onset different than those for liability to disease? 4) Are there indications of genotype by environment interaction? Are there interactions between candidate genes and exposures? 5) To what extent is liability to PD influenced by the same latent shared and non-shared environmental influences as dementia and depression, which are often co-morbid with PD?

拟议研究的主要目的是评估环境因素对帕金森氏病（PD）的重要性瑞典双胞胎的基于人群的样本。 55岁及以上的所有双胞胎在瑞典的双胞胎注册表中，目前正在接受计算机协助筛选最常见，复杂疾病的电话采访，包括PD，痴呆症和抑郁症。我们已经筛选了22,788个人，并且知道帕金森症状有多少屏幕呈阳性。在此基础上，我们项目从2000年9月之前接受采访的26,000个人，近1100个人将筛选为PD阳性。医生会检查所有潜在病例及其共同链条建立临床诊断。所有医院入院以及从中获得的病历初级卫生保健设施。一旦看到足够的病例，临床诊断将用于评估筛查的敏感性和特异性将调整用于识别正屏幕的过程和算法。出于合格确认的目的，将获得血液样本分子工作。研究环境的主要方法论方法因素将是通过使用不和谐对的。将有大约有580对双胞胎，两对都活着，与正屏幕。有关环境暴露的信息将得到确保第三方的计算机协助调查对诊断视而不见。此外，大多数双胞胎在28年前回应了有关暴露的问卷（职业，教育，住宅历史，健康状况，吸烟，饮食，环境刺激性等）。匹配的对“联合控制”分析也由于定量遗传方法将解决以下问题：1） PD不一致的双胞胎对，环境风险因素是什么在受影响的双胞胎中促进这种疾病，或保护未受影响的双？ 28年前报告的暴露的长期影响是什么？疾病发作之前？是否存在性别差异这些暴露？ 2）较早的报道报告了 Tanner及其同事的老年男女双胞胎证实了女性女性和性别对吗？ 3）是遗传和共享的相对重要性家庭环境的影响与早期PD不同？发病时代的影响与对疾病负有责任的影响有所不同吗？ 4）是否有环境相互作用的基因型的迹象？在那里候选基因与暴露之间的相互作用？ 5）在多大程度上受PD的责任受相同的潜在共享和非共享的影响环境影响是痴呆和抑郁症，它们通常是合并的与PD？

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

DOI：
10.1016/s1474-4422(11)70175-2
发表时间：
2011-10
期刊：
LANCET NEUROLOGY
影响因子：
48
作者：
Ross, Owen A.;Soto-Ortolaza, Alexandra I.;Heckman, Michael G.;Aasly, Jan O.;Abahuni, Nadine;Annesi, Grazia;Bacon, Justin A.;Bardien, Soraya;Bozi, Maria;Brice, Alexis;Brighina, Laura;Van Broeckhoven, Christine;Carr, Jonathan;Chartier-Harlin, Marie-Christine;Dardiotis, Efthimios;Dickson, Dennis W.;Diehl, Nancy N.;Elbaz, Alexis;Ferrarese, Carlo;Ferraris, Alessandro;Fiske, Brian;Gibson, J. Mark;Gibson, Rachel;Hadjigeorgiou, Georgios M.;Hattori, Nobutaka;Ioannidis, John P. A.;Jasinska-Myga, Barbara;Jeon, Beom S.;Kim, Yun Joong;Klein, Christine;Kruger, Rejko;Kyratzi, Elli;Lesage, Suzanne;Lin, Chin-Hsien;Lynch, Timothy;Maraganore, Demetrius M.;Mellick, George D.;Mutez, Eugenie;Nilsson, Christer;Opala, Grzegorz;Park, Sung Sup;Puschmann, Andreas;Quattrone, Aldo;Sharma, Manu;Silburn, Peter A.;Sohn, Young Ho;Stefanis, Leonidas;Tadic, Vera;Theuns, Jessie;Tomiyama, Hiroyuki;Uitti, Ryan J.;Valente, Enza Maria;van de Loo, Simone;Vassilatis, Demetrios K.;Vilarino-Gueell, Cartes;White, Linda R.;Wirdefeldt, Karin;Wszolek, Zbigniew K.;Wu, Ruey-Meei;Farrer, Matthew J.
通讯作者：
Farrer, Matthew J.

Personality traits and the risk for Parkinson disease: a prospective study.

人格特质和帕金森病的风险：一项前瞻性研究。

DOI：
10.1007/s10654-015-0062-1
发表时间：
2016
期刊：
European journal of epidemiology
影响因子：
13.6
作者：
Sieurin,Johanna;Gustavsson,Petter;Weibull,CarolineElise;Feldman,AdinaLeiah;Petzinger,GiselleMaria;Gatz,Margaret;Pedersen,NancyLee;Wirdefeldt,Karin
通讯作者：
Wirdefeldt,Karin

Occupational exposure in parkinsonian disorders: a 43-year prospective cohort study in men.