Establishing the Intrinsic Regenerative Capacity of the Adult Human Heart in Health and Disease and the use of Recombinant Cellular Growth Factors to Reverse Heart Failure in vitro

建立成人心脏在健康和疾病状态下的内在再生能力以及使用重组细胞生长因子在体外逆转心力衰竭

• 批准号: nhmrc : 1093852
• 负责人: Dr Sean Lal
• 金额: $ 7.38万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/establishing-intrinsic-regenerative-failure-vitro/519465
• 关键词: Establishing; Intrinsic; Regenerative; Capacity; Adult

Heart failure is a major cause of morbidity and mortality in Australia. We hope to change this bleak outlook by showing that the human heart can regenerate, thereby challenging the long-held dogma that our heart cannot regrow. Using human heart samples we will measure the intrinsic capability of these cells to regenerate in heart failure compared to what occurs in normal, healthy ageing. In addition, we will explore the use of extracellular growth factors to stimulate these heart muscle cells

心力衰竭是澳大利亚发病率和死亡率的主要原因。我们希望通过证明人类的心脏可以再生来改变这种暗淡的前景，从而挑战长期以来的教条，即我们的心脏不能再生。使用人类心脏样本，我们将测量这些细胞在心力衰竭中再生的内在能力，与正常健康衰老中发生的情况相比。此外，我们还将探索利用细胞外生长因子刺激这些心肌细胞