Mutidisciplinary Training; Brain Disorders & Development

描述（由申请人提供） 这个新的博士后项目的目标是培养年轻的科学家， 特别是医生科学家，并促进职业生涯的重点是了解 神经系统发育障碍的基本机制。 计划在与下列方面有关的科学学科进行多学科培训： 神经发育障碍的研究。因此，挑选了19名培训教员 5个部门。教师包括4名医学博士，2名医学博士/博士和13名博士。他们的 教授11人，副教授3人，助理教授5人。 Swann博士将担任项目总监，负责日常工作。 程序的操作。Zoghbi博士和Noebels博士将担任 联合主任。主要的培训领域包括遗传和分子基础， 遗传性神经发育障碍，包括：Rett综合征、Angelman综合征 综合征、脆性X综合征、唐斯综合征、Miller-Dicker无脑畸形和 全身性棘波癫痫。另一个共同的研究重点将是 神经科学实验室使用先进的成像技术， 电生理学技术来研究细胞和分子 与遗传性和获得性癫痫慢性模型相关的异常 紊乱学院的所有实验室都提供以下方面的专业知识 尖端生物技术用于动物模型的创建和研究。三 已规划了单独的培训轨道。一个是MD/PhD和MD， 丰富的基础科学研究经验。另一个是经验较少的 第三个是博士。这些后MD学生将被告知， 个别研究顾问委员会选择实验室 轮换和研究生课程。博士将接受大量的培训， 神经发育障碍的临床方面，通过临床 会议、专科诊所和医院查房。Baylor College of 医学界投入了大量资源来研究 疾病的机制，包括发育中的大脑。实验室 空间和核心实验室非常出色。小儿神经科诊所， 实验室和中心，包括NIH资助的智力迟钝研究 中心，将是博士后培养的重要资源。有 目前有84名博士后学生在培训学院的实验室， 包括14名MD/PhD，8名MD和62名PhD。通过培训新一代的 杰出的研究科学家，我们希望新的治疗方法， 治愈婴幼儿的毁灭性发育障碍， 出现。

DESCRIPTION (provided by applicant) The goal of this new postdoctoral program is to train young scientists, particularly physician scientists, and promote careers focused on understanding the basic mechanisms underlying disorders of the developing nervous system. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 19 training faculty were selected from 5 departments. The faculty includes 4 MDs, 2 MD/Ph.Ds and 13 Ph.Ds. Their ranks are: 11 Professors, 3 Associate Professors and 5 Assistant Professors. Dr. Swann will serve as Program Director and be responsible for the day-to-day operation of the program. Dr. Zoghbi and Dr. Noebels will serve as Co-Directors. Major training areas include the genetic and molecular basis of inherited neurodevelopmental disorders including: Rett Syndrome, Angelman's Syndrome, Fragile X Syndrome, Downs Syndrome, Miller-Dicker Lissencephaly and Generalized Spike-Wave Epilepsy. Another, shared focus of study will be epilepsy where neuroscience laboratories use advanced imaging and electrophysiological techniques to study the cellular and molecular abnormalities relevant to chronic models of both inherited and acquired seizure disorders. All the laboratories of the faculty provide expertise in cutting-edge biotechnology for the creation and study of animal models. Three separate training tracks are planned. One is for MD/PhDs and MDs with substantial basic science research experience. Another is for less experienced MDs and the third for PhDs. These latter MD students will be advised by individualized research advisory committees on their choice of laboratory rotations and graduate level courses. PhDs will receive substantial training in the clinical aspects of neurodevelopmental disorders through clinical conferences, subspeciality clinics and hospital rounds. Baylor College of Medicine has committed substantial resources to the study of the basic mechanisms of diseases including those of the developing brain. Laboratory space and core laboratories are outstanding. Pediatric Neurology clinics, laboratories and centers, including a NIH funded Mental Retardation Research Center, will be important resources for postdoctoral trainees. There are currently 84 postdoctoral students in the laboratories of the training faculty, including 14 MD/PhDs, 8 MDs and 62 PhDs. By training a new generation of outstanding research scientists, we hope new approaches for the treatment and cure of devastating developmental disorders in infants and young children will emerge.