Multidisciplinary Training in Brain Disorders and Development

描述（由申请人提供）：该博士后培训计划的目标是培养年轻科学家，特别是内科科学家，并促进专注于理解和开发发展性脑疾病治疗的职业。计划在与神经发育障碍研究相关的科学学科中进行多学科培训。因此，从5个系选出了21名培训教员。他们包括：3名博士，2名博士/博士和16名博士。现有教授11人，副教授4人，助理教授6人。现有博士后培养人员70人，其中博士/博士10人，博士10人，博士50人。John Swann博士将继续担任项目总监，并负责项目的日常运作。Drs。胡达·佐格比和杰夫·诺贝尔斯将继续担任联合董事。主要培训领域包括神经发育障碍的遗传和分子基础，包括但不限于：Rett综合征，Angelman综合征，脆性X染色体综合征和自闭症。另一个集中的训练领域是癫痫，研究遗传和获得性癫痫的分子基础。所有实验室都采用尖端的生物技术来创建和研究疾病的相关动物模型，不仅是为了了解这些疾病的生物学基础，而且是为了筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在目前的资助周期中，已有10名博士后进入我们的培养计划，其中6名已经成为主要大学的教职员工。其中包括3名医学博士/博士儿童神经学家，他们已经获得了K08资助，现在正在从事研究工作。提供三个培训课程。一种是具有丰富研究经验的医学博士/博士和医学博士。另一种是针对经验不足的医学博士，培训更为正式，包括实验室轮岗和研究生课程。博士们通过晚餐讨论、临床会议和亚专科诊所接受神经发育障碍临床方面的大量培训。贝勒医学院（Baylor College of Medicine）和德克萨斯儿童医院（Texas Children’s Hospital）已投入大量资源研究疾病的神经生物学，目前正在计划创建“德克萨斯儿童神经学研究所”（Texas Children’s Neurological Research Institute），该研究所有望成为未来几代博士后培训的主要中心。通过培养杰出的研究科学家，我们感到对婴幼儿毁灭性发育障碍的新的理解和治疗方法将会出现。

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists, particularly physician scientists, and promote careers focused on understating and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 21 training faculty have been selected from 5 departments. They include: 3 MDs, 2 MD/PhDs and 16 PhDs. There are: 11 Professors, 4 Associate Professors and 6 Assistant Professors. There are currently 70 postdoctoral students training in laboratories of the faculty and include 10 MD/PhDs, 10 MDs and 50 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All laboratories employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. During the current funding cycle, 10 postdoctoral students have thus far entered our training program and 6 are already faculty members at major universities. These include 3 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through Dinner Discussions, clinical conferences and subspecialty clinics. Baylor College of Medicine and Texas Children's Hospital have committed substantial resources to the study of the neurobiology of disease and are currently planning the creation of the "Texas Children's Neurological Research Institute" which promises to become a major center for postdoctoral training for generations to come. By training outstanding research scientists, we feel new understandings and treatments for the devastating developmental disorders in infants and young children will emerge.