Multidisciplinary Training in Brain Disorders and Development

脑部疾病和发育的多学科培训

• 批准号: 9411644
• 负责人: John William Swann
• 金额: $ 0.21万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9411644
• 关键词: Brain Diseases; Development; Training; multidisciplinary

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists and promote careers focused on understanding and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 23 training faculty have been selected from 4 departments. They include: 3 MDs, 7 MD/PhDs and 13 PhDs. There are: 12 Professors, 5 Associate Professors and 6 Assistant Professors. There are currently 95 postdoctoral students training in laboratories of the faculty and include 7 MD/PhDs, 11 MDs and 77 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All labs employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. Over the past years of support, 24 postdoctoral students have thus far entered our training program and 8 have accepted faculty positions at major universities. These include 4 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through dinner discussions, clinical conferences and subspecialty clinics. The opening of the Jan and Dan Duncan Neurological Research Institute (The NRI) is the most recent and dramatic demonstration of the commitment of Texas Children's Hospital and Baylor College of Medicine to the study of the neurobiology of developmental disorders. This training program is now based in the NRI, which promises to become a major center for the study of and training in developmental brain abnormalities. By training outstanding research scientists, we feel new understandings and treatments for the devastating neurological disorders of infants and young children will emerge.

描述(由申请者提供)：这个博士后培训项目的目标是培养年轻的科学家，促进专注于理解和开发发育性大脑疾病治疗方法的职业。计划在与神经发育障碍研究相关的科学学科中进行多学科培训。因此，从4个系中挑选了23名培训教师。包括：医学博士3人，医学博士7人，博士13人。现有教授12人，副教授5人，助理教授6人。现有在校博士后95人，其中医学博士7人，博士11人，博士后77人。约翰·斯旺博士将继续担任项目主任，并负责该项目的日常运作。胡达·佐格比博士和杰夫·诺贝尔斯博士将继续担任联席董事。主要培训领域包括神经发育障碍的遗传和分子基础，包括但不限于：Rett综合征、Angelman综合征、脆性X综合征和自闭症。另一个集中的训练领域是癫痫，研究遗传性和获得性癫痫的分子基础。所有实验室都使用尖端生物技术来创建和研究相关的疾病动物模型，以便不仅了解这些疾病的生物学基础，而且筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在过去的几年里，到目前为止，已有24名博士后学生参加了我们的培训计划，8名学生接受了重点大学的教师职位。这些人包括4名医学博士/博士儿童神经学家，他们已经获得了K08奖学金，现在正在从事研究工作。提供三条培训赛道。一种是面向医学博士和有丰富研究经验的医学博士。另一种是针对经验较少的医学博士，那里的培训更正规，包括实验室轮换和研究生课程。博士通过晚餐讨论、临床会议和专科诊所接受神经发育障碍临床方面的实质性培训。简和丹·邓肯神经研究所(The NRI)的成立是德克萨斯州儿童医院和贝勒医学院致力于发育障碍神经生物学研究的最新和最戏剧性的证明。这项培训计划现在设在NRI，它有望成为研究和培训发育脑异常的主要中心。通过培训优秀的研究科学家，我们认为将出现对婴幼儿破坏性神经疾病的新理解和治疗方法。