Enhanced single molecule detection with integrated 2D materials

利用集成二维材料增强单分子检测

• 批准号: 2341962
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2341962
• 关键词: Enhanced; single; molecule; detection; integrated

Most prevalent molecular detection systems rely upon fluorescence, label free approaches would open up a far greater range of molecules that can be studied. The importance of which is unequivocal, allowing for the probing of biomolecular processes, underpinning function. Further still the incorporation of 2D materials and their heterostructures offers great potential and added functionality to current techniques. Along with enabling the development of new detection strategies.This project will make use of the unique properties offered by 2D materials, as well as, tailoring them in the form of heterostructures to provide platforms for examining the elementary constituents of complex heterogenous biomolecular mixtures. Such functionality will be achieved by employing state-of-the-art micro/nano fabrication, producing 2D incorporated fluid manipulation devices.The development of which will provide unique insights into various biomedical questions, from cancer and developmental biology to the development of novel immunotherapeutic strategies and probing the onset of neurodegeneration.

大多数流行的分子检测系统依赖于荧光，无标记的方法将开辟更大范围的分子，可以研究。其重要性是明确的，允许探测生物分子过程，支持功能。此外，2D材料及其异质结构的结合为当前技术提供了巨大的潜力和附加功能。沿着新的检测策略的开发。该项目将利用2D材料提供的独特特性，并以异质结构的形式对其进行定制，为检查复杂异质生物分子混合物的基本成分提供平台。这种功能将通过采用最先进的微/纳米制造技术来实现，生产2D合并的流体操纵设备。其发展将为各种生物医学问题提供独特的见解，从癌症和发育生物学到新的免疫策略的开发和探测神经退行性疾病的发病。