Cancer Biostatistics Training Grant

癌症生物统计学培训补助金

• 批准号: 6785832
• 负责人: PHYLLIS A. GIMOTTY
• 金额: $ 13.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6785832
• 关键词: Cancer; Biostatistics; Training; Grant

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB) at the University of Pennsylvania proposes an innovative research training program in biostatistics for pre-doctoral training in cancer biostatistics, specifically designed to strengthen the links among biostatistics, clinical oncology, and clinical epidemiology. The training program relies on existing collaborative relationships among biostatistics and epidemiology faculty within the CCEB, faculty members within the Cancer Center of the University of Pennsylvania, and statistics faculty within the Wharton School of Business at the University of Pennsylvania. The objective of the program is to train individuals to be rigorous and independent academic investigators able to use the range of approaches in biostatistics to address research issues in cancer. This includes the application of general biostatistical methods, including the analysis of longitudinal data, such as tumor growth; the analysis of time-to-event data; meta-analysis; clinical trial design; and ethical issues in clinical research. This training also includes the application of specific biostatistical methods needed to address issues unique to cancer studies, such as informative censoring in the analysis of tumor growth data, as well as the development and application of novel biostatistical methods to such areas as the analysis of DNA microarray data. The four- to five-year training program for predoctoral students provides didactic training in fundamental skills, methodologies, and principles of biostatistics, with specific emphasis on the areas of most importance to cancer research. Specific courses are offered in general and advanced biostatistics and research methodology, leading toward a Ph.D. degree in Biostatistics. Students also will be required to obtain a strong background in substantive areas related to cancer, including cancer biology, cancer genetics, and cancer epidemiology. Courses are supplemented by attendance at and participation in research seminars and journal clubs. In addition, faculty mentors will lead students through directed experiences in collaborative research and consultation. Specifically, the training program is designed to: (1) provide in-depth knowledge of the biostatistics techniques appropriate to research in cancer; (2) provide research experience with mentors in biostatistics and cancer research; and (3) bring together faculty and students through participation in seminar series in the CCEB and the respective clinical departments. Strengths of the program are the emerging training program in biostatistics offered by the CCEB; the wide ranging experience of the biostatistics faculty in multiple areas of biostatistics methods and cancer research; the established teaching program in statistics offered by the Wharton School; the long history of successful research training programs in clinical epidemiology offered by the CCEB; and the collaborative links among biostatistics and epidemiology faculty within the CCEB, faculty members of the Cancer Center, and statistics faculty within the Wharton School. Available resources include several existing large databases available to students that can be tapped for biostatistics training, a broad array of ongoing research projects conducted within and outside the CCEB (e.g., clinical trials at all phases, case-control studies, cohort studies, and an increasing amount of research involving the use of DNA microarrays), Penn's commitment to collaborative research and training, and the broad range of experiences of faculty participating in this training program.

描述（由申请人提供）： 宾夕法尼亚大学临床流行病学和生物统计学中心（CCEB）提出了一项创新的生物统计学研究培训计划，用于癌症生物统计学的博士前培训，专门旨在加强生物统计学，临床肿瘤学和临床流行病学之间的联系。 该培训计划依赖于CCEB内的生物统计学和流行病学教师，宾夕法尼亚大学癌症中心的教师以及宾夕法尼亚大学沃顿商学院的统计学教师之间的现有合作关系。 该计划的目标是培养个人成为严谨和独立的学术研究人员，能够使用生物统计学的一系列方法来解决癌症的研究问题。 这包括一般生物统计方法的应用，包括纵向数据的分析，例如肿瘤生长;事件发生时间数据的分析;荟萃分析;临床试验设计;以及临床研究中的伦理问题。 该培训还包括解决癌症研究特有问题所需的特定生物统计方法的应用，例如肿瘤生长数据分析中的信息审查，以及开发和应用新的生物统计方法来分析DNA微阵列数据。 四到五年的博士前学生培训计划提供基本技能，方法和生物统计学原理的教学培训，特别强调对癌症研究最重要的领域。 具体课程提供一般和先进的生物统计学和研究方法，导致博士学位。生物统计学学位。 学生还将被要求获得与癌症相关的实质性领域的强大背景，包括癌症生物学，癌症遗传学和癌症流行病学。 课程还通过出席和参加研究研讨会和期刊俱乐部得到补充。 此外，教师导师将带领学生通过合作研究和咨询的指导经验。 具体而言，培训计划旨在：（1）提供适合癌症研究的生物统计学技术的深入知识;（2）提供生物统计学和癌症研究导师的研究经验;（3）通过参加CCEB和相应临床部门的系列研讨会，将教师和学生聚集在一起。 该计划的优势是CCEB提供的生物统计学新兴培训计划;生物统计学教师在生物统计学方法和癌症研究的多个领域的广泛经验;沃顿商学院提供的统计学既定教学计划; CCEB提供的临床流行病学成功研究培训计划的悠久历史;以及CCEB内的生物统计学和流行病学教师、癌症中心的教师和沃顿商学院内的统计学教师之间的合作联系。 现有资源包括几个现有的大型数据库，可供学生用于生物统计学培训，在CCEB内外进行的广泛的正在进行的研究项目（例如，所有阶段的临床试验、病例对照研究、队列研究以及越来越多的涉及使用DNA微阵列的研究），宾夕法尼亚大学对合作研究和培训的承诺，以及参与该培训计划的教师的广泛经验。