Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心的目标是促进福克斯的卵巢癌研究。 大通癌症中心和宾夕法尼亚大学通过提供专家实验设计， 为SPORE科学家提供生物信息学、数据管理和数据分析支持。核心成员 在应用于癌症的生物统计学和生物信息学方面具有丰富的知识和经验 research.这个高度互动的生物统计学家、生物信息学家和信息学家小组将为所有人提供服务。 孢子项目和核心，并支持未来的项目和试点研究。 生物统计和生物统计核心的具体目标是：（1）提供统计专业知识， 实验和研究的设计，包括研究方案的制定，样本量的确定， 随机化程序，以及中期审查和最终分析的计划;（2）进行临床试验 分析、数据探索和功能基因组学分析。协助口译和演示 （3）通过修改现有技术和/或开发 （4）协助撰写统计学和生物信息学部分， （5）提供以计算机为基础的工具，以便利储存和检索在 拟议的研究，从而建立和维护相关的数据库，允许访问 公共资源和信息。(6)提供可用人群的详细描述， 为当前和未来的SPORE调查人员提供资源。(7)确保数据的准确性， 通过基于软件的数据一致性和质量控制系统来管理数据库。(8)组织和维护 数据库应尽可能提高准确性和可访问性，同时保持严格的保密性。 相关性（参见说明）： 生物统计学和生物信息学核心致力于积累，管理，分发， 分析和解释卵巢癌中该孢子产生的有价值的信息。核心 成员将运用他们的量化和计算方法的知识， 研究并加速发现和验证卵巢癌的新治疗和预防策略 癌

The goal of the Biostatistics and Bioinformatics Core is to facilitate ovarian cancer research at the Fox Chase Cancer Center and the University of Pennsylvania by providing expert experimental design, bioinformatics, data management and data analysis support to SPORE scienfists. Members of the core have substanfial knowledge and experience in biostatistics and bioinformatics as applied to cancer research. This highly interactive group of biostatisticians, bioinformatics and informaticians will serve all SPORE projects and cores and support future projects and pilot studies. The specific goals of the Biostafisfics and Biostatisfics Core are to: (1) Provide stafisfical expertise in the design of experiments and studies, including research proposal development, sample size determinafion, randomization procedures, and plans for interim reviews and final analysis; (2) Perform statisfical analyses, data explorafion, and funcfional genomics analyses. Assist in the interpretation and presentation of results; (3) Develop specialized stafistical methods by modifying existing techniques and/or developing new statisfical approaches; (4) Assist with the writing of stafistical and bioinformatics components of manuscripts; (5) Provide computer-based tools to facilitate the storage and retrieval of data generated in the proposed research, thereby creating and maintaining relafional databases that permit access to common resources and informafion. (6) Provide detailed descriptions of the available populations and resources for current and future SPORE investigators. (7) Ensure the accuracy of the data maintained in the databases by software-based data consistency and quality control systems. (8) Organize and maintain the databases to maximize accuracy and accessibility while maintaining strict confidenfiality. RELEVANCE (See instructions): The Biostafistics and Bioinformatics Core is dedicated to the accumulafion, management, distribufion, analysis and interpretation of valuable information generated by this SPORE in Ovarian Cancer. Core members will apply their knowledge of quanfitative and computafional methods to facilitate translafional research and speed discovery and validafion of new therapeufic and prevention strategies for ovarian cancer.