3T Whole-Body MRI Scanner for Functional Imaging

描述（由申请人提供）：本高端仪器项目提案申请购买全身3特斯拉磁共振成像（MRI）扫描仪的资金。主要用户组由9名NIH资助的研究人员组成，其中8名从事功能性MRI研究，1名从事癌症研究。次要用户组由15名fMRI研究人员组成，每个人都有可能获得NIH的资助。主要用户来自7个院系。他们的资金包括2个P01和13个R01奖。在主要和次要用户中，有11个不同类型的基于MRI的额外拨款。威斯康星医学院的核磁共振研究项目是基于1984年购买的通用电气1.5T Signa全身扫描仪和1992年购买的3T Bruker Medspec头部扫描仪。两者都完全致力于研究，两者都接近过时。A GE SignaOT LX VWi基础系统全身扫描仪已被选中，成本为2,196,584美元。购买所需资金的余额将来自MCW来源，射频屏蔽和场地准备的费用也将来自MCW来源。在实际下订单的时候，西门子和菲利普斯的扫描仪也将被评估。MCW的fMRI团队规模庞大，资金充足。具有MRI扫描仪管理经验。支持核磁共振扫描仪的广泛基础设施已经到位。该提案的主题是加强功能磁共振成像的转化研究。MCW正在进行越来越多的临床研究，旨在将功能磁共振成像用于疾病诊断和监测治疗反应。新的扫描仪将在临床研究环境中使用，并得到MCW普通临床研究中心（GCRC）的额外支持，该中心拥有成像核心。它不会有临床服务收费的使用。MCW的fMRI小组在全国范围内的fMRI医学应用方面处于领先地位。

DESCRIPTION (provided by applicant): This High End Instrumentation Program proposal requests funds for purchase of a whole-body 3 Tesla magnetic resonance imaging (MRI) scanner. The Major User group consists of nine NIH funded investigators, eight working in functional MRI and one in Cancer research. The Minor User group consists of 15 fMRI researchers, each with potential for NIH funding. The Major Users are from seven academic departments. Their funding consists of 2 P01 and 13 R01 awards. Across Major and Minor users, there are 11 additional MRI based grants of various types. The MRI research program at the Medical College of Wisconsin is based on a General Electric 1.5T Signa whole body scanner purchased in 1984 and a 3T Bruker Medspec head-only scanner purchased in 1992. Both are totally dedicated to research and both are approaching obsolescence. A GE Signa 3.OT LX VWi Base System whole body scanner has been selected at a cost of $2,196,584. The balance of the funds required for purchase will be derived from MCW sources, as will the costs of the RF shielding and preparation of the site. At the time that the actual order is placed, scanners from Siemens and Phillips will also be evaluated. The fMRI team at MCW is large and well funded. It has experience in MRI scanner management. An extensive infrastructure for support of the MRI scanners is in place. The theme of the proposal is enhancement of translational research in fMRI. Increasingly, clinical research studies are underway at MCW that are designed to lead to the use of fMRI in diagnosis of disease and monitoring response to treatment. The new scanner will be in a clinical research environment with additional support from the General Clinical Research Center (GCRC) of MCW, which has an imaging core. It will have no clinical fee-for-service usage. The fMRI group at MCW is superbly positioned to provide leadership at a national level in the use of fMRI in medicine.