Real-Time Motion Correction and Increased Scan-Session Sucess in Clinical MRI

临床 MRI 中的实时运动校正和提高扫描会话成功率

• 批准号: 7684030
• 负责人: JAMES S HYDE
• 金额: $ 45.15万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684030
• 关键词: Address; Adoption; Algorithms; Alzheimer' s Disease; Base of the Brain; Behavior; Behavioral; Behavioral Paradigm; Brain; Brain Mapping; Brain Neoplasms; Chest wall structure; Clinical; Complex; Computers; Current Procedural Terminology Codes; Data; Data Quality; Dependence; Dependency; Detection; Disease; Ensure; Evaluation; Eye; Failure; Fatigue; Functional Magnetic Resonance Imaging; Funding; Goals; Head; Head and neck structure; Image; Image Analysis; Immunity; Individual; Insurance; Lead; Left; Length; MRI Scans; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Morphologic artifacts; Motion; Motor; Movement; National Center for Research Resources; Noise; Operative Surgical Procedures; Patient Noncompliance; Patients; Pattern; Performance; Physicians; Physics; Physiologic pulse; Physiological; Procedures; Process; Randomized; Relative (related person); Research; Resolution; Scanning; Signal Transduction; Slice; Source; Speech; System; Systems Integration; Techniques; Technology; Test Result; Testing; Time; Variant; Vision; Weight; Wisconsin; Work; base; clinically relevant; compliance behavior; coping; data acquisition; evaluation/testing; falls; image registration; improved; instrumentation; magnetic field; medical schools; meetings; mild neurocognitive impairment; novel; programs; sensory stimulus; statistics; success; time use; tool; visual motor

DESCRIPTION (provided by applicant): Three fMRI CPT codes (for clinical billing and insurance) have been approved and went into effect January 1, 2007. Clinical fMRI will expand rapidly. However, clinical fMRI is often confounded by excessive patient motion. Studies are lost and subjects need to be recalled. Moreover, during the fMRI scan, patients must adequately perform a behavioral task, which can suffer if they become fatigued or fall asleep. Functional MRI studies often take too long. These two problems-patient motion/performance and scan-session length-are the focus of this proposal. Improved methodology is the goal. The three aims address the problems from different perspectives: Aim 1: Pulse sequences and imaging physics for separation of fMRI signals from motion artifacts; Aim 2: Real-time statistics and image analysis for shortening scan duration and improvement of noise immunity; Aim 3: Management of scan-session duration with adaptive acquisition paradigms, multi-parameter mapping, and real-time clinically relevant displays. The aims come together in multifaceted interactive attacks on the two problems. Motion-contaminated data will either be fixed in real time or censored in real time accompanied by additional data acquisition. On a voxel-by-voxel basis, adaptive Kalman filtering will adjust baseline variation caused by slow-motion drift. Higher receiver bandwidth can reduce motion artifacts in several ways. We will explore use of receiver bandwidths as high as 1 MHz, with correspondingly higher gradient strengths. At its essence, this is a study of physiological noise relative to scanner preamplifier noise. As for scan-session length, studies should not extend longer than necessary for statistically significant results, which requires real-time statistical analysis. Randomized multiplexed behavioral paradigms reduce test time. In addition, all of the foregoing techniques will be implemented in near-real time through the use of increased computer power in the MRI scanner suite. In the end, we seek a clinically relevant determination of scan-session success before the patient leaves the scanner, allowing fMRI to be used in a conventional test/retest paradigm. This will significantly improve the success rate of fMRI exams and thereby facilitate the adoption of fMRI as a routine clinical tool. Research will be performed on a GE 3T scanner that was purchased in 2005 using funds made available through the High End Instrumentation Program of the National Center for Research Resources. The work will be carried out by one of the pioneering groups in fMRI. The potential impact of fMRI on brain-related disease is enormous. References are made in the proposal to two specific studies underway at the Medical College of Wisconsin: subjects with mild cognitive impairment that may lead to Alzheimer's disease, and fMRI mapping of visual, motor, and speech function prior to surgical treatment of brain tumors. There are many more.

描述(申请人提供)：三个fMRI CPT代码(用于临床计费和保险)已获得批准，并于2007年1月1日生效。临床功能磁共振成像将迅速发展。然而，临床功能磁共振成像经常被患者过度的运动所混淆。研究丢失了，受试者需要召回。此外，在fMRI扫描期间，患者必须充分执行一项行为任务，如果他们感到疲惫或睡着了，可能会受到影响。功能核磁共振研究通常需要太长时间。这两个问题-患者运动/性能和扫描会话长度-是本提案的重点。改进方法是我们的目标。这三个目标从不同的角度解决问题：目标1：用于将fMRI信号与运动伪影分离的脉冲序列和成像物理；目标2：用于缩短扫描持续时间和提高抗噪性的实时统计和图像分析；目标3：通过自适应采集范例、多参数映射和实时临床相关显示来管理扫描会话持续时间。这两个目标在对这两个问题的多方面互动攻击中汇聚在一起。受运动污染的数据将被实时修复或被实时审查，并伴随着额外的数据采集。在逐个体素的基础上，自适应卡尔曼滤波将调整由慢动作漂移引起的基线变化。较高的接收器带宽可以在几个方面减少运动伪影。我们将探索使用高达1 MHz的接收器带宽，具有相应更高的梯度强度。从本质上讲，这是一种相对于扫描仪前置放大器噪声的生理噪声研究。至于扫描时段长度，研究的持续时间不应超过统计上显著结果所需的时间，这需要实时的统计分析。随机化的多路行为范例减少了测试时间。此外，通过在MRI扫描仪套件中使用增加的计算机能力，所有上述技术将近乎实时地实施。最后，我们寻求在患者离开扫描仪之前对扫描会话成功与否进行临床相关的确定，从而允许在传统的测试/重新测试范例中使用功能磁共振成像。这将显著提高功能磁共振检查的成功率，从而促进功能磁共振作为常规临床工具的采用。研究将在2005年购买的GE 3T扫描仪上进行，该扫描仪使用国家研究资源中心高端仪器计划提供的资金。这项工作将由功能磁共振领域的一个先驱小组进行。功能磁共振成像对大脑相关疾病的潜在影响是巨大的。该提案提到了威斯康星医学院正在进行的两项具体研究：患有可能导致阿尔茨海默病的轻度认知障碍的受试者，以及脑肿瘤手术治疗前视觉、运动和语言功能的fMRI映射。还有更多。