Upgrade of GE 3.0T SIGNA MRI Scanner for Enhanced Neuroimaging

描述(由申请人提供)：此共享仪器提案用于将通用电气现有的研究专用3T磁共振扫描仪从版本11B升级到版本15。该扫描仪于2005年安装，资金来自NCRR(S10 RR017215)的高端仪器奖。威斯康星医学院(MCW)生物物理学教授詹姆斯·S·海德博士是该提案的PI，并再次担任该提案的PI。生物物理系占据了MCW校区一座研究大楼的一楼，扫描仪安装在一座专门建造的一层建筑中，附属于大楼与系楼层相同的水平，提供了非常方便的通道。这座单层建筑的建设资金由MCW提供，表明该机构对成像研究提供了大量支持。该扫描仪专门用于神经成像。尽管有许多医院和医疗设施紧邻妇幼保健院校园，但这种扫描仪没有临床收费服务的使用。它完全致力于研究。来自MCW许多部门的研究人员，包括基础科学和临床，都利用了这一设施。这次升级对用户群体有四大好处：(1)大大改进了梯度驱动器；(2)最先进的扩散张量成像；(3)将8通道磁头线圈、8通道接收器和成像软件升级到16通道，用于传感成像；以及(4)将控制界面升级到目前的水平。关于效益(4)，该扫描仪将是MCW临床转化科学研究所(CTSI)成像核心的一个关键方面，并将被MCW、马奎特大学和威斯康星大学密尔沃基分校的跨大学研究人员使用。对于旨在进行早期翻译研究的项目，控制界面必须是最新的，这一点很重要。来自九个主要资助用户的十个项目被描述。此外，还以表格形式汇总了14个较小用户的项目。MCW的MRI生物物理学研究团队具有开创性的技术进步的悠久历史，包括非常早期的关于表面线圈的论文(20世纪80年代)，使用从共享仪器奖购买的60厘米布鲁克扫描仪进行的3T早期人体研究(90年代)，第一篇发表在功能磁共振上的论文(1992)，功能连接磁共振的发现(FcMRI)(1995)，以及实时功能磁共振的最早报告。同样，MCW神经科学团队长期以来一直处于以下领域的成像研究前沿：语音和语言处理、癫痫的术前映射、视觉和视觉注意、运动控制和计时、涉及药物成瘾的神经系统、脑瘤成像以及阿尔茨海默病的早期检测。本提案中描述的项目涵盖了从这些开创性贡献演变而来的广泛的成像科学、神经科学和翻译研究。此次升级将加强集中磁共振资源的共享使用，丰富正在进行的研究，促进新的研究方向，培育合作和互动的研究环境，并促进神经科学的多学科方法。 与公众健康相关：功能磁共振成像(FMRI)继续是一项快速发展的技术，不断揭示关于健康和患病人脑的新信息。这项共享仪器升级现有研究专用3特斯拉MRI扫描仪的提议将为使用该仪器的研究人员带来许多优势，其中最重要的是使用同时从大脑获取的16个通道的数据获得更高的灵敏度-即所谓的感知成像。申请者是功能磁共振成像开发和应用的先驱。

DESCRIPTION (provided by applicant): This shared instrumentation proposal is for upgrade of an existing research-dedicated General Electric 3T MRI scanner from Version 11B to Version 15. This scanner was installed in 2005 using funds from a high-end instrumentation award from NCRR (S10 RR017215). James S. Hyde, Ph.D., Professor of Biophysics at the Medical College of Wisconsin (MCW) was PI of that proposal and serves again as PI of this proposal. The Department of Biophysics occupies the ground floor of a research tower on the MCW campus, and the scanner was installed in a purpose-built, one-story building attached to the tower at the same level as the departmental floor, providing very convenient access. Funds for construction of this one-story building were provided by MCW, indicating substantial support of imaging research by the institution. The scanner is used exclusively for Neuroimaging. Although there are numerous hospitals and medical facilities immediately adjacent to the MCW campus, there is no clinical fee-for-service usage of this scanner. It is dedicated totally to research. Investigators from numerous departments of MCW, both basic science and clinical, make use of the facility. This upgrade has four major benefits for the user community: (1) greatly improved gradient drivers; (2) state-of- the-art diffusion tensor imaging; (3) upgrade of the eight-channel head coil, eight-channel receiver, and image- formation software to 16 channels for SENSE imaging; and (4) upgrade of the control interface to current levels. With respect to benefit (4), this scanner will be a key aspect of the Clinical Translational Science Institute (CTSI) Imaging Core at MCW and will be employed by investigators across university boundaries at MCW, Marquette University, and the University of Wisconsin-Milwaukee. It is felt to be important that the control interface be up to date for projects intended for early stage translational research. Ten projects are described from nine major funded users. In addition, projects are summarized in tabular form for 14 minor users. The MRI Biophysics research team at MCW has a long history of pioneering technological advances, including very early papers on surface coils (1980s), early human studies at 3T using a 60-cm Bruker scanner that was purchased from a shared instrumentation award (1990s), the first paper to be published on fMRI (1992), the discovery of functional connectivity MRI (fcMRI) (1995), and the earliest report of real-time fMRI. Similarly, the MCW Neuroscience team has long been at the forefront of imaging research on speech and language processing, presurgical mapping in epilepsy, vision and visual attention, motor control and timing, neural systems involved in drug addiction, brain tumor imaging, and early detection of Alzheimer's disease. Projects described in this proposal cover the wide range of imaging science, neuroscience, and translational research that has evolved from these pioneering contributions. The upgrade will enhance the shared use of the centralized MRI resources, enrich ongoing research, promote new research directions, foster a cooperative and interactive research environment, and stimulate multidisciplinary approaches to neuroscience. PUBLIC HEALTH RELEVANCE: Functional magnetic resonance imaging (fMRI) continues to be a rapidly evolving technique that continues to reveal new information about both the healthy and the diseased human brain. This shared instrumentation proposal to upgrade an existing research-dedicated 3 Tesla MRI scanner will have many advantages for the investigators who use the instrument, of which the most important is higher sensitivity using 16 channels of data acquired from the brain simultaneously-so-called SENSE imaging. The applicants are pioneers in the development and application of fMRI.