Upgrade of GE 3.0T SIGNA MRI Scanner for Enhanced Neuroimaging

升级 GE 3.0T SIGNA MRI 扫描仪以增强神经影像

• 批准号: 7793194
• 负责人: JAMES S HYDE
• 金额: $ 50万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-18 至 2012-02-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793194
• 关键词: Alzheimer' s Disease; Arts; Award; Basic Science; Biophysics; Brain; Brain Neoplasms; Clinical; Communities; Computer software; Data; Development; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Drug Addiction; Early Diagnosis; Environment; Epilepsy; Fee-for-Service Plans; Floor; Fostering; Functional Magnetic Resonance Imaging; Funding; Head; Hospitals; Human; Image; Institutes; Institution; Magnetic Resonance Imaging; Maps; Medical; Minor; National Center for Research Resources; Neurosciences; Paper; Publishing; Recording of previous events; Reporting; Research; Research Personnel; Resources; Science; Speech; Staging; Surface; System; Techniques; Time; Translational Research; Universities; Vision; Visual attention; Wisconsin; improved; instrument; instrumentation; interdisciplinary approach; language processing; medical schools; motor control; neuroimaging; professor; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): This shared instrumentation proposal is for upgrade of an existing research-dedicated General Electric 3T MRI scanner from Version 11B to Version 15. This scanner was installed in 2005 using funds from a high-end instrumentation award from NCRR (S10 RR017215). James S. Hyde, Ph.D., Professor of Biophysics at the Medical College of Wisconsin (MCW) was PI of that proposal and serves again as PI of this proposal. The Department of Biophysics occupies the ground floor of a research tower on the MCW campus, and the scanner was installed in a purpose-built, one-story building attached to the tower at the same level as the departmental floor, providing very convenient access. Funds for construction of this one-story building were provided by MCW, indicating substantial support of imaging research by the institution. The scanner is used exclusively for Neuroimaging. Although there are numerous hospitals and medical facilities immediately adjacent to the MCW campus, there is no clinical fee-for-service usage of this scanner. It is dedicated totally to research. Investigators from numerous departments of MCW, both basic science and clinical, make use of the facility. This upgrade has four major benefits for the user community: (1) greatly improved gradient drivers; (2) state-of- the-art diffusion tensor imaging; (3) upgrade of the eight-channel head coil, eight-channel receiver, and image- formation software to 16 channels for SENSE imaging; and (4) upgrade of the control interface to current levels. With respect to benefit (4), this scanner will be a key aspect of the Clinical Translational Science Institute (CTSI) Imaging Core at MCW and will be employed by investigators across university boundaries at MCW, Marquette University, and the University of Wisconsin-Milwaukee. It is felt to be important that the control interface be up to date for projects intended for early stage translational research. Ten projects are described from nine major funded users. In addition, projects are summarized in tabular form for 14 minor users. The MRI Biophysics research team at MCW has a long history of pioneering technological advances, including very early papers on surface coils (1980s), early human studies at 3T using a 60-cm Bruker scanner that was purchased from a shared instrumentation award (1990s), the first paper to be published on fMRI (1992), the discovery of functional connectivity MRI (fcMRI) (1995), and the earliest report of real-time fMRI. Similarly, the MCW Neuroscience team has long been at the forefront of imaging research on speech and language processing, presurgical mapping in epilepsy, vision and visual attention, motor control and timing, neural systems involved in drug addiction, brain tumor imaging, and early detection of Alzheimer's disease. Projects described in this proposal cover the wide range of imaging science, neuroscience, and translational research that has evolved from these pioneering contributions. The upgrade will enhance the shared use of the centralized MRI resources, enrich ongoing research, promote new research directions, foster a cooperative and interactive research environment, and stimulate multidisciplinary approaches to neuroscience. PUBLIC HEALTH RELEVANCE: Functional magnetic resonance imaging (fMRI) continues to be a rapidly evolving technique that continues to reveal new information about both the healthy and the diseased human brain. This shared instrumentation proposal to upgrade an existing research-dedicated 3 Tesla MRI scanner will have many advantages for the investigators who use the instrument, of which the most important is higher sensitivity using 16 channels of data acquired from the brain simultaneously-so-called SENSE imaging. The applicants are pioneers in the development and application of fMRI.

描述（由申请人提供）：本共享仪器提案旨在将现有研究专用通用电气3 T MRI扫描仪从版本11B升级至版本15。该扫描仪于2005年安装，使用的资金来自NCRR的高端仪器奖（S10 RR 017215）。James S. Hyde博士，威斯康星州医学院（MCW）的生物物理学教授是该提案的PI，并再次担任该提案的PI。生物物理学系位于MCW校园的一座研究塔的底层，扫描仪安装在一座专门建造的单层建筑中，与该塔位于同一楼层，提供非常方便的访问。这座单层建筑的建造资金由MCW提供，表明该机构对成像研究的大力支持。该扫描仪专门用于神经成像。虽然有许多医院和医疗设施紧邻MCW校园，有没有临床收费服务使用这种扫描仪。它完全致力于研究。来自MCW许多部门的研究人员，包括基础科学和临床，利用该设施。该升级对用户群体有四个主要好处：（1）梯度驱动器大大改进;（2）最先进的弥散张量成像;（3）将8通道头部线圈、8通道接收器和成像软件升级为16通道，用于SENSE成像;（4）将控制界面升级为当前水平。关于受益（4），该扫描仪将成为MCW临床转化科学研究所（CTSI）成像核心的一个关键方面，并将由MCW、马奎特大学和威斯康星大学密尔沃基分校的跨大学边界的研究者使用。它被认为是重要的是，控制接口是最新的项目打算为早期阶段的转化研究。报告介绍了九个主要供资用户的十个项目。此外，还以表格形式为14个小用户概述了项目。MCW的MRI生物物理学研究团队在开拓技术进步方面有着悠久的历史，包括关于表面线圈的早期论文（20世纪80年代），使用从共享仪器奖购买的60厘米布鲁克扫描仪在3 T下进行的早期人类研究（20世纪90年代），第一篇关于功能MRI的论文（1992年），功能连接MRI（fcMRI）的发现（1995年），也是最早的实时功能磁共振成像报告同样，MCW神经科学团队长期以来一直处于语音和语言处理成像研究的最前沿，癫痫的术前映射，视觉和视觉注意力，运动控制和计时，涉及药物成瘾的神经系统，脑肿瘤成像和阿尔茨海默病的早期检测。本提案中描述的项目涵盖了从这些开创性贡献发展而来的广泛的成像科学，神经科学和转化研究。此次升级将加强中央MRI资源的共享使用，丰富正在进行的研究，促进新的研究方向，培养合作和互动的研究环境，并刺激神经科学的多学科方法。 公共卫生关系：功能性磁共振成像（fMRI）仍然是一种快速发展的技术，不断揭示有关健康和患病人脑的新信息。这种共享仪器的建议，以升级现有的研究专用的3特斯拉MRI扫描仪将有许多优势，为研究人员谁使用的仪器，其中最重要的是更高的灵敏度使用16通道的数据采集从大脑不寻常的所谓的SENSE成像。申请人是fMRI开发和应用的先驱。