MAGNETIC RESONANCE UPDATE: PULSED EPR, ENDOR, ELDOR

描述（由申请人提供）：本申请申请为1993年购买的布鲁克ESP 380E型脉冲电子顺磁共振（EPR）光谱仪的升级提供资金，以继续支持NIH支持的七个研究项目，涉及六个不同机构的研究人员。我们寻求通过获得带有ENDOR和ELDOR配件的现代控制台和微波桥架，将该仪器更新到新的最先进的ElexSys 580的水平。对于每个用户组，EPR测量要么是他们NIH拨款的特定目标，要么是EPR测量将解决研究中关键路径上的问题。所请求的更新将对所有主要用户产生明显的影响，具体请参见个别用户描述。其优点包括：在重复率受当前光谱仪硬件限制的系统中，提高了灵敏度；通过消除相干噪声和“Tx”噪声提高灵敏度和分辨率；消除当前的硬件限制，在重要的数据区域中间产生空白的“窗口”；提高了ENQOR， TRIPLE和ENQOR光谱的分辨率，目前分辨率受到硬件对脉冲宽度的限制；由于现在需要手动调整的许多光谱仪控制由计算机控制，因此可以更好地利用夜间和周末运行；它将使利用脉冲序列和进行测量成为可能，这些测量目前由于光谱仪硬件和软件的任意限制而无法进行。

DESCRIPTION (provided by applicant): This application requests funds for the upgrade of a pulsed electron paramagnetic resonance (EPR) spectrometer, a Bruker ESP 380E purchased in 1993, in order to provide continued support for seven research projects with NIH support involving researchers at six different institutions. We seek to update this instrument to the level of a new state-of-the-art ElexSys 580 by obtaining a modern console and a microwave bridge with ENDOR and ELDOR accessories.For each user group, the EPR measurements are either a specific aim of their NIH grants or the EPR measurements will resolve a problem on the critical path in the research. The requested update will have clear impact on all of the major users as detailed in the individual user descriptions. The benefits include: Increased sensitivity in systems where the repetition rate is limited by the current spectrometer hardware; Increased sensitivity and resolution from the elimination of coherent noise and 'Tx' noise; Elimination of current hardware limitations that produce blank 'windows' in middle of important regions of data; Increased resolution in ENDOR, TRIPLE and ENQOR spectra where resolution is currently limited by hardware limitations on pulse width; Better utilization of overnight and weekend runs resulting from computer control of many spectrometer controls that now require manual adjustment; It will make it possible to employ pulse sequences and make measurements that are currently prevented by arbitrary limitations in the hardware and software of the spectrometer.