MAGNETIC RESONANCE UPDATE: PULSED EPR, ENDOR, ELDOR

描述（由申请人提供）：本申请要求提供资金，用于升级脉冲电子顺磁共振（EPR）光谱仪，即1993年购买的Bruker ESP 380 E，以便为NIH支持的涉及六个不同机构研究人员的七个研究项目提供持续支持。我们试图通过获得一个现代化的控制台和一个带有ENDOR和ELDOR附件的微波桥来将这个仪器更新到一个新的最先进的ElexSys 580的水平。对于每个用户组，EPR测量要么是他们NIH赠款的一个特定目标，要么EPR测量将解决研究中关键路径上的一个问题。所要求的更新将对所有主要用户产生明显影响，详情见个人用户说明。这些好处包括：通过消除相干噪声和“Tx”噪声提高了灵敏度和分辨率;消除了在重要数据区域中间产生空白“窗口”的当前硬件限制;提高了ENDOR、TRIPLE和ENQOR光谱的分辨率，其中分辨率当前受到脉冲宽度硬件限制的限制;更好地利用计算机控制的许多光谱仪控制，现在需要手动调整，导致夜间和周末运行;它将使人们有可能采用脉冲序列，并进行测量，目前阻止在硬件和软件的光谱仪的任意限制。

DESCRIPTION (provided by applicant): This application requests funds for the upgrade of a pulsed electron paramagnetic resonance (EPR) spectrometer, a Bruker ESP 380E purchased in 1993, in order to provide continued support for seven research projects with NIH support involving researchers at six different institutions. We seek to update this instrument to the level of a new state-of-the-art ElexSys 580 by obtaining a modern console and a microwave bridge with ENDOR and ELDOR accessories.For each user group, the EPR measurements are either a specific aim of their NIH grants or the EPR measurements will resolve a problem on the critical path in the research. The requested update will have clear impact on all of the major users as detailed in the individual user descriptions. The benefits include: Increased sensitivity in systems where the repetition rate is limited by the current spectrometer hardware; Increased sensitivity and resolution from the elimination of coherent noise and 'Tx' noise; Elimination of current hardware limitations that produce blank 'windows' in middle of important regions of data; Increased resolution in ENDOR, TRIPLE and ENQOR spectra where resolution is currently limited by hardware limitations on pulse width; Better utilization of overnight and weekend runs resulting from computer control of many spectrometer controls that now require manual adjustment; It will make it possible to employ pulse sequences and make measurements that are currently prevented by arbitrary limitations in the hardware and software of the spectrometer.