MICROSPECT IN TUMOR IMAGING

描述（由申请人提供）： GammaMedica X-Spect，双探测器组合SPECT CT系统利用两个镶嵌碘化钠晶体单光子放射性核素探测器，安装在带有微型CT（用于解剖相关性和衰减测量）的旋转机架上，以记录小动物的高分辨率SPECT数据。放射性核素探测器在平行孔准直器的表面处具有1 mm的分辨率，并且当采用0.5mm针孔准直器时，具有约0.5mm的分辨率。GammaMedica显微镜是唯一一款针对小动物成像而优化的商用系统。MicroSPECT系统专为啮齿类动物成像而设计，与大视场临床仪器记录的数据相比具有重大优势。该设备提供了上级空间分辨率、易用性以及将放射性核素数据与高分辨率计算机断层扫描相关联的能力。使用该仪器记录的数据将增强从正在进行的NIH资助项目中获得的信息。X-SPECT设备的优点包括：空间分辨率上级于microPET，能够同时对不同能量的多个示踪剂成像，结合用户友好的图像采集和分析系统，以及使用市售单光子发射放射性核素进行研究的相对优势。11名受资助的研究人员将利用该仪器提供的最先进的能力，加强他们在基因表达、肿瘤生长率、细胞凋亡和靶向治疗研究方面的工作。使用多个标签，区域肿瘤灌注，激素受体表达和细胞凋亡可以在同一只动物中同时进行评估，治疗前，治疗期间和治疗后，包括许多新的药物，放射性和放射性核素治疗正在开发的纪念。在SKI，这种仪器的理想设置，microSPECT将是一个宝贵的辅助迅速扩大小动物成像计划。

DESCRIPTION (provided by applicant): The GammaMedica X-Spect, dual detector combined SPECT CT system utilizes two mosaic sodium-iodide crystal single photon radionuclide detectors mounted on a rotating gantry with a micro CT (for anatomic correlation and attenuation measurements), to record high resolution SPECT data on small animals. The radionuclide detectors have 1-mm resolution at the surface of a parallel hole collimator, and about 0.5mm when a 0.5mm pinhole collimator is employed. The GammaMedica microspect is the only commercially available system optimized for imaging small animals. The MicroSPECT system, specifically designed for rodent imaging, offers major advantages over the data that can be recorded with large field of view clinical instruments. The device offers superior spatial resolution, ease of use, and the ability to correlate the radionuclide data with high resolution computed tomography. Data recorded with this instrument will enhance the information obtained from ongoing NIH funded programs. Advantages of the X-SPECT device include: spatial resolution superior to microPET, ability to image multiple tracers of different energies simultaneously, incorporation of a user friendly system for image acquisition and analysis, and the relative advantage of using commercially available single-photon-emitting radionuclides for research studies. Eleven funded investigators will utilize the state-of-the-art capabilities offered by this instrument to enhance their work on studies of gene expression, tumor growth rate, apoptosis and targeted therapy. Using multiple labels, regional tumor perfusion, hormone receptor expression and apoptosis can be assessed simultaneously in the same animal, prior to, during, and after treatment, including the many novel drug, radiation, and radionuclide therapies being developed at Memorial. At SKI, an ideal setting for such an instrument, the microSPECT will be an invaluable adjunct to the rapidly expanding small-animal imaging program.