MICROSPECT IN TUMOR IMAGING

肿瘤成像中的显微观察

• 批准号: 6580730
• 负责人: HARRY W STRAUSS
• 金额: $ 43.5万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580730
• 关键词: apoptosis; biomedical equipment purchase; gene expression; neoplastic growth; radionuclide imaging /scanning; single photon emission computed tomography

DESCRIPTION (provided by applicant): The GammaMedica X-Spect, dual detector combined SPECT CT system utilizes two mosaic sodium-iodide crystal single photon radionuclide detectors mounted on a rotating gantry with a micro CT (for anatomic correlation and attenuation measurements), to record high resolution SPECT data on small animals. The radionuclide detectors have 1-mm resolution at the surface of a parallel hole collimator, and about 0.5mm when a 0.5mm pinhole collimator is employed. The GammaMedica microspect is the only commercially available system optimized for imaging small animals. The MicroSPECT system, specifically designed for rodent imaging, offers major advantages over the data that can be recorded with large field of view clinical instruments. The device offers superior spatial resolution, ease of use, and the ability to correlate the radionuclide data with high resolution computed tomography. Data recorded with this instrument will enhance the information obtained from ongoing NIH funded programs. Advantages of the X-SPECT device include: spatial resolution superior to microPET, ability to image multiple tracers of different energies simultaneously, incorporation of a user friendly system for image acquisition and analysis, and the relative advantage of using commercially available single-photon-emitting radionuclides for research studies. Eleven funded investigators will utilize the state-of-the-art capabilities offered by this instrument to enhance their work on studies of gene expression, tumor growth rate, apoptosis and targeted therapy. Using multiple labels, regional tumor perfusion, hormone receptor expression and apoptosis can be assessed simultaneously in the same animal, prior to, during, and after treatment, including the many novel drug, radiation, and radionuclide therapies being developed at Memorial. At SKI, an ideal setting for such an instrument, the microSPECT will be an invaluable adjunct to the rapidly expanding small-animal imaging program.

描述（由申请人提供）： GammaMedica X-Spect 双探测器组合 SPECT CT 系统利用两个镶嵌碘化钠晶体单光子放射性核素探测器，安装在带有微型 CT 的旋转机架上（用于解剖关联和衰减测量），记录小动物的高分辨率 SPECT 数据。放射性核素探测器在平行孔准直器表面的分辨率为 1 毫米，当使用 0.5 毫米针孔准直器时，分辨率约为 0.5 毫米。 GammaMedica 显微镜是唯一一款针对小动物成像进行优化的商用系统。 MicroSPECT 系统专为啮齿动物成像而设计，与使用大视场临床仪器记录的数据相比，具有重大优势。该设备提供卓越的空间分辨率、易于使用，并且能够将放射性核素数据与高分辨率计算机断层扫描相关联。使用该仪器记录的数据将增强从正在进行的 NIH 资助项目中获得的信息。 X-SPECT 设备的优点包括：优于 microPET 的空间分辨率、同时对不同能量的多个示踪剂进行成像的能力、采用用户友好的图像采集和分析系统以及使用市售单光子发射放射性核素进行研究的相对优势。十一名受资助的研究人员将利用该仪器提供的最先进的功能来加强他们在基因表达、肿瘤生长率、细胞凋亡和靶向治疗方面的研究工作。使用多种标记，可以在治疗前、治疗期间和治疗后同时评估同一动物的局部肿瘤灌注、激素受体表达和细胞凋亡，包括纪念馆正在开发的许多新药、放射和放射性核素疗法。 SKI 是此类仪器的理想设置，microSPECT 将成为快速扩展的小动物成像项目的宝贵辅助工具。

项目成果

Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose.

使用单链抗体/链霉亲和素构建体和放射性标记的 DOTA-生物素进行预靶向放射免疫治疗：减少肾脏剂量的策略。

• 发表时间: 2006
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Förster,GregorJ;Santos,ElmerB;Smith-Jones,PeterM;Zanzonico,Pat;Larson,StevenM
• 通讯作者: Larson,StevenM