HEART IMAGING WITH SINGLE PHOTON AGENTS
HEART IMAGING WITH SINGLE PHOTON AGENTS
批准号:
3344031
负责人:
HARRY W STRAUSS
金额:
$14.66万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-12-01 至 1988-11-30
中文摘要
严重高血压大鼠,早期充血性
英文摘要
Severely hypertensive Dahl strain rats, in the early stages of congestive
heart failure, demonstrated focal zones of reduced fatty acid uptake in
their left ventricular endocardium and free wall. The decrease in fatty
acid uptake was accompanied by a complimentary increase in glucose uptake,
although perfusion remained uniform. These observations suggest that in
the chronically pressure overloaded, hypertrophied, ventricle, metabolic
and functional changes occur in temporal proximity. The observation that
'dysfunctional' myocardium has decreased fatty acid uptake while perfusion
is uniform suggests that measurement of regional fatty acid uptake will be
useful as an indicator of the contractile integrity of the myocardium. To
test this hypothesis we propose to perform serial measurements of fatty
acid uptake, perfusion, ventricular function and myocardial ultrastructure
in Dahl strain rats with evolving myocardial hypertrophy due to severe
hypertension. When the relationship of changes in fatty acid uptake,
function and morphometry are defined, two drug intervention studies will be
performed in additional groups of rats. The first study will test the
ability of early therapy with calcium channel blockers and beta blockade to
prevent the decrease of fatty acid uptake and function. The second study
will determine if therapy with digoxin, calcium channel blockade, or beta
blockade started after rest left ventricular ejection fraction has
decreased can prevent further deterioration of fatty acid uptake and
function. In parallel with the animal studies, patients with left
ventricular hypertrophy will be evaluated by planar and SPECT imaging of
the distribution of fatty acid, left ventricular function and perfusion.
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会议论文
MICROSPECT IN TUMOR IMAGING
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批准号:6580730
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项目类别:
-
资助金额:$43.5万
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财政年份:2003
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负责人:HARRY W STRAUSS
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依托单位:
HEART IMAGING WITH SINGLE PHOTON AGENTS
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批准号:3344033
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项目类别:
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资助金额:$30.47万
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财政年份:1988
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负责人:HARRY W STRAUSS
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依托单位:
HEART IMAGING WITH SINGLE PHOTON AGENTS
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批准号:3344029
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项目类别:
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资助金额:$24.77万
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财政年份:1988
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负责人:HARRY W STRAUSS
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依托单位:
HEART IMAGING WITH SINGLE PHOTON AGENTS
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批准号:3344032
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项目类别:
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资助金额:$27.31万
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财政年份:1988
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负责人:HARRY W STRAUSS
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依托单位:
HEART IMAGING WITH SINGLE PHOTON AGENTS
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批准号:3344030
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项目类别:
-
资助金额:$16.6万
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财政年份:1985
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负责人:HARRY W STRAUSS
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依托单位:
HEART IMAGING WITH SINGLE PHOTON AGENTS
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批准号:3344028
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项目类别:
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资助金额:$18.67万
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财政年份:1985
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负责人:HARRY W STRAUSS
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依托单位:
FATTY ACID ANALOGUES FOR MYOCARDIAL IMAGING
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批准号:3340757
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项目类别:
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资助金额:$15.33万
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财政年份:1983
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负责人:HARRY W STRAUSS
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依托单位:
CARDIOVASCULAR NUCLEAR MEDICINE TRAINING GRANT
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批准号:3540910
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项目类别:
-
资助金额:$12.36万
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财政年份:1978
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负责人:HARRY W STRAUSS
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依托单位:
CARDIOVASCULAR NUCLEAR MEDICINE TRAINING GRANT
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批准号:3540911
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项目类别:
-
资助金额:$11.69万
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财政年份:1978
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负责人:HARRY W STRAUSS
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依托单位:
CARDIOVASCULAR NUCLEAR MEDICINE TRAINING GRANT
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批准号:3540909
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项目类别:
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资助金额:$8.64万
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财政年份:1978
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负责人:HARRY W STRAUSS
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依托单位:
国内基金
海外基金
Acoustic Cardiography在心力衰竭患者危险分层及预后评估中的应用研究
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批准号:81300244
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项目类别:青年科学基金项目
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资助金额:23.0万元
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批准年份:2013
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负责人:王上
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依托单位: