FATTY ACID ANALOGUES FOR MYOCARDIAL IMAGING

用于心肌成像的脂肪酸类似物

• 批准号: 3340757
• 负责人: HARRY W STRAUSS
• 金额: $ 15.33万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3340757
• 关键词: biochemistry; blood glucose; cardiac output; chemical models; exercise; fatty acid analog; fatty acid metabolism; free fatty acids; heart imaging /visualization /scanning; homeostasis; image processing; myocardium; palmitates

A modified radiolabled fatty acid, 3-methyl-[1-11C]-heptadecanoate (MFA), was developed in our laboratory for the evaluation of regional myocardial metabolism. The radiopharmaceutical localized in the hearts of experimental animals and man with a residence half time approximately 100 times longer than palmitate. Preliminary isolated organ perfusion experiments suggested that metabolism was via omega oxidation. The proposed research will characterize both the biochemical pathways employed in the metabolism of this substance and the kinetic behavior of the material in a manner suitable for application to a metabolic model. This model will define the parameters that must be known to relate the regional distribution of MFA in the myocardium to the regional metabolism of fatty acids under a wide variety of circumstances. Specific studies will be performed comparing MFA to palmitate in isolated perfused organs and in dogs to characterize the biochemical pathways and determine the effect of hypoxia, acidosis, and availability of alternative substrates on myocardial fatty acid behavior. Studies will also be performed in human volunteers to establish the changes in MFA myocardial behavior from rest to exercise, and following ingestion of a meal. Finally, a second MFA, 3,15-dimethyl-[1-11C]-hepatadecanoate, will be synthesized and tested in isolated perfused organs. This substance should not be metabolized by either beta or omega oxidation, and my provide an additional imaging probe to study myocardial fatty acid metabolism.

一种改性的放射性脂肪酸，3-甲基-[1-11C]-十七烷酸酯（MFA），

项目成果

Metabolism of beta-methyl-heptadecanoic acid in the perfused rat heart and liver.

β-甲基-十七烷酸在灌注大鼠心脏和肝脏中的代谢。

• 发表时间: 1990
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Fink,GD;Montgomery,JA;David,F;Garneau,M;Livni,E;Elmaleh,D;Strauss,HW;Brunengraber,H
• 通讯作者: Brunengraber,H

Measurement of both left ventricular function and regional myocardial perfusion with 133Xe in dogs.

用 133Xe 测量狗的左心室功能和局部心肌灌注。

• DOI: 10.1007/bf00296092
• 发表时间: 1987
• 期刊: European journal of nuclear medicine
• 作者: Ruddy,TD;Yasuda,T;Barlai-Kovach,M;Nedelman,MA;Moore,RH;Alpert,NM;Correia,JA;Newell,JB;Okada,RD;Boucher,CA
• 通讯作者: Boucher,CA

Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement.

• DOI: 10.1126/science.3975623
• 发表时间: 1985-03
• 期刊: Science
• 影响因子: 56.9
• 作者: Yoshiharu Yonekura;A. Brill;Peter M. Som;K. Yamamoto;Suresh C. Srivastava;J. Iwai;David R. Elmaleh;E. Livni;Strauss Hw;M. Goodman

New radionuclides for cardiac imaging.

用于心脏成像的新放射性核素。

• DOI: 10.1016/0033-0620(86)90025-3
• 发表时间: 1986
• 期刊: Progress in cardiovascular diseases
• 影响因子: 9.1
• 作者: Miller,DD;Gill,JB;Fischman,AJ;Callahan,RJ;Elmaleh,DR;Boucher,CA;Strauss,HW
• 通讯作者: Strauss,HW

Radiopharmaceuticals for cardiac imaging.

用于心脏成像的放射性药物。

• 发表时间: 1985
• 期刊: Radiologic clinics of North America
• 影响因子: 1.9
• 作者: Miller,DD;Elmaleh,DR;McKusick,KA;Boucher,CA;Callahan,RJ;Strauss,HW
• 通讯作者: Strauss,HW