Skin Cooling to Improve Orthostatic Tolerance

皮肤冷却以提高直立耐受力

• 批准号: 6690032
• 负责人: CRAIG G CRANDALL
• 金额: $ 26.3万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690032
• 关键词: baroreflex; body temperature; cardiovascular disorder therapy; cardiovascular function; clinical research; cold temperature; cryotherapy; extraterrestrial environment; gravity; human subject; human therapy evaluation; intracardiac volume; patient oriented research; postural hypotension; skin

DESCRIPTION (provided by applicant): Post-space flight orthostatic hypotension/intolerance occurs in 25 to 66 percent of crew members upon returning to a 1 G environment. The mechanism(s) causing this response are not completely understood. Identification of countermeasures to reduce the incidence of orthostatic intolerance associated with space flight is paramount to NASA's mission. One such countermeasure may be skin surface cooling. In light of this, three specific objectives will be accomplished by the proposal work: 1) Identify an optimal skin surface cooling paradigm that causes the largest increase in autonomic responses (i.e. stroke volume, blood pressure, sympathetic nerve activity, etc.) without causing shivering or altering motor function. 2) Identify the mechanisms by which skin surface cooling increases the aforementioned autonomic responses resulting in improved tolerance to orthostatic stress. 3) Identify whether skin surface cooling is an effective countermeasure to improve orthostatic tolerance in men and women following simulated microgravity exposure using the head-down tilt bed rest model. Upon completion of the proposed studies important information will be provided that will be beneficial for both operational and safety concerns for astronauts, as well as to individuals who suffer from idiopathic orthostatic intolerance.

描述（由申请人提供）：太空飞行后恢复 25% 至 66% 的船员出现低血压/不耐受 返回到 1G 环境。引起这种反应的机制不是 完全明白了。确定减少影响的对策 与太空飞行相关的直立不耐受的发生率至关重要 到美国宇航局的使命。其中一种对策可能是皮肤表面冷却。在 有鉴于此，该提案将实现三个具体目标 工作：1) 确定最佳的皮肤表面冷却范例，该范例会导致 自主反应（即每搏输出量、血压、 交感神经活动等），不会引起颤抖或运动改变 功能。 2) 确定皮肤表面冷却增加的机制 上述自主反应导致耐受性提高 直立应力。 3) 确定皮肤表面冷却是否有效 提高男性和女性术后直立耐受力的对策 使用头朝下倾斜卧床模型模拟微重力暴露。之上 完成拟议研究后将提供重要信息： 将有利于宇航员的操作和安全问题，因为 以及患有特发性直立不耐受的个体。