New CVD risk factors for lowered congitive functioning

导致认知功能降低的新 CVD 危险因素

• 批准号: 6721496
• 负责人: MERRILL F ELIAS
• 金额: $ 47.3万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6721496
• 关键词: apolipoprotein E; behavioral /social science research tag; blood chemistry; cardiovascular disorder epidemiology; clinical research; cognition; disease /disorder proneness /risk; gene environment interaction; homocysteine; human data; human subject; hypertension; psychological tests; tobacco abuse

DESCRIPTION: Arterial hypertension and high blood pressure (BP) are major risk factors for cardiovascular disease (CVD) and stroke; they are also risk factors for lowered cognitive functioning. Except for diabetes, there have been comparatively few studies of other common risk factors, particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability. This study is concerned with associations between cognitive functioning and three major CVD risk factors: (1) BP, (2) high total plasma homocysteine (tHcy), and (3) ApoE e4 genotype. Although high BP is a well-established risk factor for lowered cognitive functioning, tHcy and ApoE e4 are relatively unexplored variables with respect to cognitive functioning. A major objective is to investigate the individual, cumulative, and synergistic effects of BP, tHcy levels, and ApoE e4 genotype on cognitive functioning over a broad range of cognitive abilities. Three secondary, but important, objectives are to determine: (1) the extent to which the adverse influence of these three CYD risk factors on cognitive functioning is affected by the presence of coexisting CVD risk factors (e.g., cigarette smoking); (2) the cumulative impact of multiple risk factors on cognitive functioning; (3) the extent to which age effects on cognitive functioning are attenuated by adjustment for BP, tHey, ApoE genotype, and other CVD risk factors. The study makes use of existing data from a large longitudinal study of hypertension and cognitive functioning. Additionally, important new information about relations among tHey, ApoE, and BP will be obtained by calling back the longitudinal subjects for additional studies of cognitive functioning and making use of concurrent, prospective, and retrospective analyses.

描述：动脉高血压和高血压是主要的危险因素。 心血管疾病(CVD)和中风的危险因素；它们也是危险因素 认知功能减退。除了糖尿病，还有 对其他常见风险因素的研究相对较少，特别是在 关于可能产生不利影响的风险因素之间的相互关系 认知能力。这项研究关注的是认知能力与 功能和三个主要心血管危险因素：(1)血压，(2)高总血浆 同型半胱氨酸(THcy)；(3)载脂蛋白E e4基因。尽管高BP是一种 认知功能、tHcy和ApoE降低的公认危险因素 就认知功能而言，E4是相对未被研究的变量。一个 主要目标是调查个体、累积和协同 血压、同型半胱氨酸水平和载脂蛋白E e4基因对认知功能的影响 广泛的认知能力。三个次要但重要的， 目标是确定：(1) 这三个认知功能障碍的危险因素是受 存在并存的心血管疾病危险因素(如吸烟)； 多种危险因素对认知功能的累积影响；(3) 年龄对认知功能的影响通过以下方式减弱的程度 调整血压、他们、载脂蛋白E基因和其他心血管疾病危险因素。 这项研究利用了来自一项大型纵向研究的现有数据 高血压和认知功能。此外，重要的新信息 关于他们、ApoE和BP之间的关系，将通过回调 认知功能和认知功能附加研究的纵向主题 利用同步、前瞻性和回溯性分析。