Arterial stiffness, blood pressure and cognition

动脉僵硬度、血压和认知

• 批准号: 7120545
• 负责人: MERRILL F ELIAS
• 金额: $ 66.7万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120545
• 关键词: age difference; aorta; behavioral /social science research tag; blood pressure; brain circulation; cardiovascular disorder diagnosis; cardiovascular disorder risk; carotid artery; clinical research; cognition disorders; diagnosis design /evaluation; disease /disorder proneness /risk; heart contraction; human subject; hypertension; longitudinal human study; mental health epidemiology; neuropsychological tests; prognosis; psychological aspect of aging; psychometrics; pulse pressure wave; questionnaires; vascular resistance

Our overall study hypothesis is that arterial stiffness plays an increasingly important role in the relationship between high blood pressure (BP) and lowered cognitive performance with advancing age and is an independent risk factor for lowered cognitive performance. Aortic pulse wave velocity (aPWV) and related measures (Augmentation Index) are reliable and valid indices of arterial stiffness. We propose to call back 900 individuals participating in longitudinal studies of brachial BP and cognitive performance for a new study relating arterial stiffness to cognitive performance. We will also introduce new central aortic and carotid BP measures and relate them to cognitive functioning. All of the current investigations relating BP to cognitive performance have employed the traditional pressure-cuff method of assessing BP at the brachial artery (a peripheral BP assessment). We will introduce applanation tonometry technology. This will allow us to examine relations between aPWV and cognitive functioning, as well as "closer to the brain" arterial (aortic and carotid) BP estimates and cognitive functioning. Among our major hypotheses are: (1) aPWV will be an independent predictor of cognitive performance; (2) aPWV will exhibit a greater magnitude of association with cognitive performance for older than for younger persons; (3) magnitude of associations between the site-specific BP variables and cognitive functioning will be ordered as follows, highest to lowest, carotid BP> aortic BP> brachial BP; (4) greater differences among these pressures will be observed for systolic than diastolic pressure and for younger than older adults. The hypothesized relations will hold despite statistical adjustment for variables which confound relations between BP and cognitive performance and may confound relations between aPWV and cognitive performance. As an ancillary benefit of these new studies, we will continue a 29-year longitudinal study relating brachial artery BP to cognitive performance, thus allowing us to examine both linear and non-linear relations between brachial BP and changes in performance with age.

我们的总体研究假设是，随着年龄的增长，动脉僵硬度在高血压（BP）和认知能力下降之间的关系中发挥着越来越重要的作用，并且是认知能力下降的独立风险因素。主动脉脉搏波速度（aPWV）和相关测量（增强指数）是可靠和有效的动脉僵硬度指标。我们建议召回900名参与肱动脉血压和认知能力纵向研究的个体，进行一项将动脉僵硬度与认知能力相关的新研究。我们还将介绍新的中央主动脉和颈动脉血压测量方法，并将其与认知功能联系起来。目前所有关于BP与认知能力的研究都采用了传统的压力袖带法评估肱动脉的BP（外周BP评估）。我们将介绍压平眼压测量技术。这将使我们能够检查aPWV和认知功能之间的关系，以及“更接近大脑”的动脉（主动脉和颈动脉）BP估计和认知功能。我们的主要假设是：（1）aPWV将是认知能力的独立预测因子;（2）aPWV与老年人认知能力的相关性大于年轻人;（3）部位特异性BP变量与认知功能之间的相关性大小顺序如下：从高到低，颈动脉BP>主动脉BP>肱动脉BP;（4）收缩压与舒张压之间的差异更大，年轻人与老年人之间的差异更大。尽管对混淆BP和认知表现之间关系并可能混淆aPWV和认知表现之间关系的变量进行了统计调整，但假设的关系仍将成立。作为这些新研究的辅助受益，我们将继续进行一项29年的纵向研究，将肱动脉BP与认知能力联系起来，从而使我们能够检查肱动脉BP与年龄变化之间的线性和非线性关系。