AGE, RISK FACTORS FOR CVD AND COGNITIVE FUNCTIONING

年龄、CVD 危险因素和认知功能

• 批准号: 6351622
• 负责人: MERRILL F ELIAS
• 金额: $ 25.74万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351622
• 关键词: age difference; aging; cardiovascular disorder; clinical research; cognition disorders; disease /disorder proneness /risk; gender difference; health behavior; human data; human middle age (35-64); human old age (65+); longitudinal human study

DESCRIPTION (Adapted from the Applicant's Abstract): The Framingham Heart study is a major epidemiological investigation of prospective relationships between risk factors for the development of cardiovascular disease (CVD risk factors) and CVD risk factor outcomes (Dawber' 1980; D'Agostino & Kannel, 1998). The Framingham Study and other large, prospective studies have resulted in an extensive literature on the impact of CVD risk factors (including age) and CVD outcomes. Comparatively, there have been many fewer studies of the impact of CVD risk factors on cognitive functioning, and possibly no studies of the effect of objectively measured, competing risk [actors on cognitive functioning. We will use cardiovascular risk factor data from the Framingham Heart Study (N= 2,123) in a prospective design allowing us to relate CVD risk factors (including age and gender) to two outcome measures: (1) level of cognitive performance and (2) change in cognitive performance over a 10 years longitudinal study period. Our overall goals are to deter nine the best multivariate combination of biological and psychosocial risk factors for the prediction of lowered cognitive ability in middle-aged and elderly men and women, and to evaluate the relative impact of age, gender, and other biological and psychosocial risk factors on cognitive functioning.

描述（改编自申请人的摘要）：弗雷明汉心脏研究 是一项关于未来关系的重大流行病学调查 发生心血管疾病的危险因素（CVD危险因素） 和 CVD 危险因素结果（Dawber' 1980；D'Agostino & Kannel，1998）。这 弗雷明汉研究和其他大型前瞻性研究得出了 关于 CVD 危险因素（包括年龄）和 CVD 影响的大量文献 结果。相比之下，关于其影响的研究较少。 CVD 危险因素对认知功能的影响，可能还没有相关研究 客观测量的竞争风险的影响[认知因素 发挥作用。 我们将使用弗雷明汉心脏研究中的心血管危险因素数据（N= 2,123）前瞻性设计使我们能够将 CVD 风险因素联系起来 （包括年龄和性别）两个结果指标：（1）认知水平 表现和 (2) 10 年来认知表现的变化 纵向学习期。我们的总体目标是阻止九个最好的 生物和心理社会危险因素的多变量组合 中老年男性认知能力下降的预测 女性，并评估年龄、性别和其他生物学因素的相对影响 以及影响认知功能的心理社会风险因素。