New CVD risk factors for lowered congitive functioning

导致认知功能降低的新 CVD 危险因素

• 批准号: 6861118
• 负责人: MERRILL F ELIAS
• 金额: $ 45.07万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6861118
• 关键词: apolipoprotein E; behavioral /social science research tag; blood chemistry; cardiovascular disorder epidemiology; clinical research; cognition; disease /disorder proneness /risk; gene environment interaction; homocysteine; human data; human subject; hypertension; psychological tests; tobacco abuse

DESCRIPTION: Arterial hypertension and high blood pressure (BP) are major risk factors for cardiovascular disease (CVD) and stroke; they are also risk factors for lowered cognitive functioning. Except for diabetes, there have been comparatively few studies of other common risk factors, particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability. This study is concerned with associations between cognitive functioning and three major CVD risk factors: (1) BP, (2) high total plasma homocysteine (tHcy), and (3) ApoE e4 genotype. Although high BP is a well-established risk factor for lowered cognitive functioning, tHcy and ApoE e4 are relatively unexplored variables with respect to cognitive functioning. A major objective is to investigate the individual, cumulative, and synergistic effects of BP, tHcy levels, and ApoE e4 genotype on cognitive functioning over a broad range of cognitive abilities. Three secondary, but important, objectives are to determine: (1) the extent to which the adverse influence of these three CYD risk factors on cognitive functioning is affected by the presence of coexisting CVD risk factors (e.g., cigarette smoking); (2) the cumulative impact of multiple risk factors on cognitive functioning; (3) the extent to which age effects on cognitive functioning are attenuated by adjustment for BP, tHey, ApoE genotype, and other CVD risk factors. The study makes use of existing data from a large longitudinal study of hypertension and cognitive functioning. Additionally, important new information about relations among tHey, ApoE, and BP will be obtained by calling back the longitudinal subjects for additional studies of cognitive functioning and making use of concurrent, prospective, and retrospective analyses.

描述：动脉高血压和高血压（BP）是主要的危险

项目成果

Cardiovascular health and arterial stiffness: the Maine-Syracuse Longitudinal Study.

• DOI: 10.1038/jhh.2013.131
• 发表时间: 2014-07
• 期刊: Journal of human hypertension
• 影响因子: 2.7

Parameters of Left Ventricular Mass and Dementia: Moving the Literature Forward.

左心室质量参数和痴呆：推动文献向前发展。

• DOI: 10.1161/hypertensionaha.117.10371
• 发表时间: 2018
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Elias,MerrillF;Torres,RachaelV;Davey,Adam
• 通讯作者: Davey,Adam

Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings.

基于社区的样本中习惯性巧克力消费与动脉僵硬的关系：初步发现。

• DOI: 10.1159/000445876
• 发表时间: 2016
• 期刊: Pulse (Basel, Switzerland)
• 作者: Crichton,GeorginaE;Elias,MerrillF;Alkerwi,Ala'a;Stranges,Saverio;Abhayaratna,WalterP
• 通讯作者: Abhayaratna,WalterP

Higher yogurt intake is associated with lower blood pressure in hypertensive individuals: Cross-sectional findings from the Maine-Syracuse Longitudinal study.

高血压患者较高的酸奶摄入量与较低的血压有关：缅因州-锡拉丘兹纵向研究的横断面研究结果。

• DOI: 10.1016/j.idairyj.2021.105159
• 发表时间: 2021
• 期刊: International dairy journal
• 影响因子: 3.1
• 作者: Wade,AlexandraT;Guenther,BenjaminA;Ahmed,FayezaS;Elias,MerrillF
• 通讯作者: Elias,MerrillF

Intake of Lutein-Rich Vegetables Is Associated with Higher Levels of Physical Activity.

• DOI: 10.3390/nu7095378
• 发表时间: 2015-09-18
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Crichton G;Elias M;Alkerwi A;Buckley J
• 通讯作者: Buckley J