CORE--MRI

核磁共振成像

• 批准号: 6989548
• 负责人: ERIK C WIENER
• 金额: $ 6.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989548
• 关键词: bioimaging /biomedical imaging; biomedical facility; cytology; magnetic resonance imaging; molecular oncology; neoplasm /cancer; neoplasm /cancer diagnosis

Molecular and cellular imaging by magnetic resonance(MR) provides real time in vivo analyses of the physiological, cellular, and molecular processes that occur in living tissues and their responses to medical interventions. New imaging techniques can monitor changes in tumor volume, tumor vascular permeability, cell-specific biochemical markers, protein expression, intratumoral drug concentrations and metabolism, and cell recruitment. The purpose of the newly proposed MRI Facility is to provide state of the art MR imaging (MRI) of both small animals and cancer patients, to support research activities of UPCI members. The specific aims of the Facility are: (1) Provide comprehensive state of the art MRI methods, to support both basic and clinical scientific efforts in an economic and comprehensive fashion. These services include molecular and cellular imaging techniques, by supplying pulse sequence design and implementation, imaging protocol development, contrast agent synthesis, and data analyses package development services; (2) To provide consultation by the appropriate experts in the design and application of relevant MRI methods, so that UPCI members can knowledgeably choose the most suitable technique for their research; (3) To provide access to the appropriate instrumentation and the technical, physical, and intellectual skills to carry out these techniques, so that UPCI members will be able to utilize efficient and cutting edge imaging methods in a convenient and economical fashion, including pulse sequence design and implementation, imaging protocol development, contrast agent syntheses, and data analyses package development. During the past year, UPCI has recruited two new faculty members with expertise in cancer imaging, and in parallel, in recent years both the University of Pittsburgh and Carnegie Mellon University, working closely together, have invested heavily in both small animal and human MRI fystems. The funds requested for this new Facility will provide partial support for individuals with the technical expertise, purchase of supplies, and provide imaging time, so that UPCI investigators can use in vivo molecular and cellular methods to gain new and noninvasive insights into the physiology, biology, and biochemistry of cancer, at a minimal cost, which are expected to lead to advances in the accurate diagnosis of primary and metastatic tumors, and the assessment of responses to therapy for cancer.

通过磁共振（MR）通过磁共振成像（MR）对生物组织中发生的生理，细胞和分子过程进行实时分析及其对医疗干预措施的反应。新成像技术可以监测肿瘤体积的变化，肿瘤血管通透性，细胞特异性生化标记，蛋白质表达，肿瘤内药物浓度和代谢以及细胞募集。新的目的 提出的MRI设施是为小动物和癌症患者提供最先进的MR成像（MRI），以支持UPCI成员的研究活动。该设施的具体目的是：（1）提供全面的最先进的MRI方法，以经济和全面的方式支持基本和临床科学工作。这些服务包括分子和细胞成像技术，通过提供脉冲序列设计和实施，成像协议开发，造影剂合成以及数据分析包装开发服务； （2）在相关MRI方法的设计和应用方面提供适当专家的咨询，以便UPCI成员可以熟悉其研究最合适的技术； （3）为执行这些技术提供适当的仪器以及技术，物理和智力技能，以便UPCI成员将能够以方便且经济的方式利用高效且最前沿的成像方法，包括脉冲序列设计和实现，成像协议开发，对比代理，并分析包装的开发。在过去的一年中，UPCI招募了两名具有癌症成像专业知识的新教师，并且近年来，匹兹堡大学和卡内基·梅隆大学（University of Pittsburgh）和卡内基·梅隆大学（Carnegie Mellon University）都紧密合作，在小动物和人类MRI FYSTEMS上都投入了大量投资。该新设施要求的资金将为具有技术专业知识，购买供应并提供成像时间的个人提供部分支持，以便UPCI调查人员可以在体内分子和细胞方法中使用新的和无创的洞察力，以获取对生理学，生物学，生物学，生物学，生物化学的生物学，在癌症的最小成本中，预期的及时及其准确性地及时诊断的癌症的生物化学，并有效期，该指标的生物化学和生物化学量是准确的。评估对癌症治疗的反应。