Dynamic Measurement of Brain Metabolism in Schizophrenia

描述(由申请人提供)： 此R21/R33提案的目标是应用我们最近开发的一种非常快速的磁共振(MR)数据累加方法！为了在连续或脉冲刺激后获得短至10-120s的动态代谢数据，从而能够显示以其他方式无法检测到的几个选定代谢物的瞬时时间动态变化。我们选择将这种方法应用于精神分裂症患者的评估，使用3特斯拉磁共振扫描仪来确定代谢物的动态变化是否将这些患者与正常对照组区分开来。我们预计，这种新的动态分析技术将提供一种新的工具来可视化以前无法获得的大脑活动的动态维度，从而提高我们对疾病过程的理解。此外，这项技术将提供一种新的快速评估药物效果的方法，以及一种在出现全面精神病之前检测疾病非常早期阶段的潜在方法。

DESCRIPTION (provided by applicant): The goal of this R21/R33 proposal is to apply a very rapid Magnetic Resonance (MR) data accumulation method, which we have recently developed! in order to obtain dynamic metabolic data over periods as short as 10-120s after presenting either a continuous or a pulsed stimulus, and thus be able to demonstrate transient temporal dynamic changes in several selected metabobites, that could not be detected otherwise. We have elected to apply this method to the evaluation of patients with schizophrenia by using a 3 Tesla MR scanner to determine whether dynamic changes in metabolites differentiate these patients from normal controls. We anticipate that this new dynamic analytical technique will provide a new tool to visualize a previously unavailable dynamic dimension of brain activity and that it will thus improve our understanding of the disease process. In addition, this technique will provide a new rapid method for evaluation of drug effects, and a potential method for detecting very early stages of the disease prior to the manifestation of a full-blown psychosis.