Dynamic Measurement of Brain Metabolism in Schizophrenia

精神分裂症脑代谢的动态测量

• 批准号: 6846761
• 负责人: DAVID N GUILFOYLE
• 金额: $ 17.2万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6846761
• 关键词: analytical method; brain metabolism; brain morphology; clinical research; drug adverse effect; early diagnosis; functional magnetic resonance imaging; human subject; interview; medical records; mental disorder diagnosis; method development; neuropsychological tests; rapid diagnosis; schizophrenia

DESCRIPTION (provided by applicant): The goal of this R21/R33 proposal is to apply a very rapid Magnetic Resonance (MR) data accumulation method, which we have recently developed! in order to obtain dynamic metabolic data over periods as short as 10-120s after presenting either a continuous or a pulsed stimulus, and thus be able to demonstrate transient temporal dynamic changes in several selected metabobites, that could not be detected otherwise. We have elected to apply this method to the evaluation of patients with schizophrenia by using a 3 Tesla MR scanner to determine whether dynamic changes in metabolites differentiate these patients from normal controls. We anticipate that this new dynamic analytical technique will provide a new tool to visualize a previously unavailable dynamic dimension of brain activity and that it will thus improve our understanding of the disease process. In addition, this technique will provide a new rapid method for evaluation of drug effects, and a potential method for detecting very early stages of the disease prior to the manifestation of a full-blown psychosis.

描述（由申请人提供）： 该R21/R33提案的目标是应用我们最近开发的非常快速的磁共振（MR）数据累积方法！以便在呈现连续或脉冲刺激之后，在短至10- 120秒的时间内获得动态代谢数据，并且因此能够证明在几个所选代谢物中的瞬时时间动态变化，这在其他情况下是不能检测到的。我们选择应用这种方法来评价精神分裂症患者，通过使用3特斯拉MR扫描仪，以确定代谢物的动态变化是否将这些患者与正常对照区分开来。我们预计，这种新的动态分析技术将提供一种新的工具，以可视化以前不可用的大脑活动的动态维度，从而提高我们对疾病过程的理解。此外，这项技术将提供一种新的快速方法来评估药物的影响，并为检测疾病的非常早期阶段之前，一个全面的精神病的表现的潜在方法。