A multi-modal approach to deep phenotyping frailty

深度表型衰弱的多模式方法

• 批准号: 2392325
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2392325
• 关键词: multi; modal; approach; deep; phenotyping

This PhD project will combine state-of-the art magnetic resonance imaging and stable isotope tracer techniques to characterise the pathophysiology of frailty from pre-frail > frail > hyper-frail. It will involve in vivo MR based quantification of brain architecture and regional and whole-body muscle and fat volumes, alongside magnetic resonance based dynamic measures of brain perfusion and cardiac output, and stable isotope quantification of chronic muscle protein synthesis and immune function in pre-frail, frail and hyper-frail people. These measurements will be dovetailed with accepted measures of cognitive and functional ability, including mobility. This approach will provide powerful multi-disciplinary insight of the frail phenotype and also catalyse new research focused on interventions to stimulate positive adaptation in these populations.

该博士项目将结合最先进的磁共振成像和稳定同位素示踪技术，以表征从前衰弱>衰弱>超衰弱的衰弱病理生理学特征。它将涉及基于体内磁共振的大脑结构以及局部和全身肌肉和脂肪体积的量化，以及基于磁共振的脑灌注和心输出量的动态测量，以及脆弱前、脆弱和超脆弱人群的慢性肌肉蛋白合成和免疫功能的稳定同位素定量。这些测量将与公认的认知和功能能力（包括活动能力）测量相吻合。这种方法将为脆弱表型提供强大的多学科见解，并促进以干预措施为重点的新研究，以刺激这些人群的积极适应。