Obesity-mediated dysregulation in the expression & action of myostatin:

肥胖介导的表达失调

• 批准号: 2393876
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2393876
• 关键词: Obesity; mediated; dysregulation; expression; action

Full title: Obesity-mediated dysregulation in the expression and action of myostatin: A novel intrinsic mechanism that contributes to age-related sarcopenia and sensitivity to insulinThe project involves the application of a wide range of biochemical, molecular and cellular biology techniques (including primary human cell culture, transcriptomic analysis and bioinformatics) in adipose and skeletal muscle tissues obtained from healthy volunteers from different age and weight categories. This approach will help us understand the cellular mechanism(s) by which adiposity and fat accumulation within human skeletal muscle affect the regulation of the protein myostatin (a known negative regulator of skeletal muscle mass), how this contributes to sarcopenia (loss of muscle mass with age) and the development of insulin resistance (one of the hallmarks of the metabolic syndrome), and to identify candidate therapeutic strategies. The knowledge generated from this work will have important implications for the development of interventions to improve musculoskeletal ageing, one of the biggest health challenges of the 21st century.The PhD student will benefit from working in two highly regarded, independent laboratories in UK acquiring a range of human in vivo and ex vivo research skills. The student is expected to spend considerable time (6-9 months) in the research laboratories of Nestle, the world's largest Nutrition, Health and Welfare company, receiving training in transcriptomic analysis and bioinformatics.

全标题：肥胖介导的肌生成抑制素表达和作用失调：一种导致年龄相关性肌少症和胰岛素敏感性的新颖内在机制该项目涉及在从健康获得的脂肪和骨骼肌组织中应用广泛的生化、分子和细胞生物学技术（包括原代人类细胞培养、转录组分析和生物信息学） 来自不同年龄和体重类别的志愿者。这种方法将帮助我们了解人类骨骼肌内肥胖和脂肪堆积影响蛋白质肌生长抑制素（一种已知的骨骼肌质量负调节剂）调节的细胞机制，这如何导致肌肉减少症（肌肉质量随着年龄的增长而减少）和胰岛素抵抗（代谢综合征的标志之一）的发展，并确定候选治疗策略。这项工作产生的知识将对改善肌肉骨骼衰老的干预措施的开发产生重要影响，这是21世纪最大的健康挑战之一。博士生将受益于在英国两个备受推崇的独立实验室的工作，获得一系列人类体内和离体研究技能。学生预计将在全球最大的营养、健康和福利公司雀巢的研究实验室度过相当长的时间（6-9个月），接受转录组分析和生物信息学方面的培训。