Strength Training Using NMES for Children with CP

使用 NMES 对 CP 儿童进行力量训练

• 批准号: 6732340
• 负责人: SAMUEL C.K. LEE
• 金额: $ 30.58万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6732340
• 关键词: biomechanics; cerebral palsy; clinical research; exercise; functional ability; gait; human subject; longitudinal human study; middle childhood (6-11); muscle strength; musculoskeletal disorder therapy; neuromuscular stimulator; patient oriented research; rehabilitation; striated muscles

DESCRIPTION (provided by applicant): Cerebral palsy (CP) has the highest lifetime economic cost and net cost of medical care compared to the most common birth defects. Reduced muscle strength affects functional abilities in children with CP. Volitional strength training in children with CP can produce substantial gains in force production with concomitant gains in function. Volitional strength training, however, may not be optimal for producing strength gains in this population due to reduced voluntary muscle activation. Neuromuscular electrical stimulation (NMES) activates a greater number of motor units and produces higher firing rates of the active motor units than can be obtained volitionally. Thus, NMES may offer advantages over volitional exercise programs for producing gains in force production. The proposed research is designed to develop improved rehabilitation techniques for children with CP. This study compares the effects of a 12-week NMES isometric strength-training program to 12 weeks of traditional isometric strength training in children with CP. A no-exercise control group with CP will also be studied. The specific aims are: 1) To compare the force generating, volitional activation, contractile and fatigue characteristics of the quadriceps femoris and triceps surae muscles in typically developing children and children with CP; 2) to assess the ability of NMES strength training to increase quadriceps femoris and triceps surae muscle force-generating ability as compared to volitional strength training and a no-exercise control group in children with CP; 3) to assess the mechanisms underlying improvements in force-generating ability of the quadriceps femoris and triceps surae after strength training in children with CP; and 4) to assess the ability of strength training to improve gross motor function and gait in children with CP. This work will help clinicians design rehabilitation strategies based on the physiologic differences in skeletal muscle and mechanisms for force production between children with CP and children of typical development. Increasing muscle force-generating ability of children with CP can improve a child's function during activities such as sitting, standing and walking.

描述（由申请人提供）：与最常见的先天缺陷相比，脑瘫（CP）的终身经济成本和净成本最高。肌肉力量降低会影响CP儿童的功能能力。 CP儿童的自愿性训练可以在功能中带来巨大的力量产生增长。但是，由于自愿肌肉激活减少，自愿训练可能并不是在该人群中产生强度增长的最佳选择。神经肌肉电刺激（NME）激活更多的电动机单元，并产生活性电动机单元的发射速率高于自愿性。因此，NME可能会提供优于自愿性锻炼计划，以产生力生产收益。 拟议的研究旨在为CP儿童开发改进的康复技术。这项研究比较了为期12周的NMES等轴测强度训练计划与CP儿童的传统等轴测强度训练的影响。还将研究一个具有CP的无运动控制组。具体目的是：1）比较股股四头肌和三头肌肌肉的产生力，自愿性激活，收缩和疲劳特征。 2）评估NMES力量训练的能力增加了股股四头肌和三头肌的肌肉肌肉产生能力，与意志力训练和CP儿童的无运动对照组相比； 3）评估在CP儿童的力量训练后，股股骨肌和三头肌的力量的改善机制； 4）评估力量训练改善CP儿童总体运动功能和步态的能力。 这项工作将帮助临床医生根据骨骼肌的生理差异以及CP儿童与典型发育儿童之间的力量生产的生理差异来设计康复策略。在坐着，站立和步行等活动期间，增加CP儿童的肌肉力量产生能力可以改善孩子的功能。