Bone Strength: Measurment and Clinical Applications

描述(由申请人提供)： 申请者的主要职业目标是阐明运动在青春期和青春期骨骼力量发展中的作用。当骨强度降低(如骨质疏松)或超过(如创伤)时，就会发生骨折，这是骨材料和结构特性(骨大小和结构)的产物。这一领域的进展受到限制，因为最先进的骨临床工具，双能X射线吸收法(DXA)，不评估骨几何和结构，而骨强度的重要贡献因素。然而，对DXA数据应用磁共振成像(MRI)和软件算法可以获得所需的骨几何信息。研究计划。将进行两个实验，1)建立磁共振成像(MRI)和DXA在体内评估骨骼几何形状和抗弯强度的准确性；2)使用两种新技术(MRI和DXA结构分析)确定青少年体力活动对年轻成年人骨骼几何形状的影响。说教训练。该教育项目将由3名共同导师负责：医学博士Tim Mosher将负责与MRI有关的所有方面；SCD Tom Beck将负责与DXA衍生的结构分析有关的所有方面；Tom Lloyd博士将负责与保护人类受试者、数据分析、手稿和赠款准备有关的所有方面。预期效果。拟议的研究和教育计划将建立测量骨骼几何的新方法，有助于我们理解童年时期锻炼对成人骨骼强度的作用，并使应聘者能够使用评估骨骼几何和肌肉质量的新方法建立独立的研究计划。

DESCRIPTION (provided by applicant): The major career goals of the applicant are to elucidate the role of exercise on the development of bone strength during adolescence and young adulthood. Fractures occur when bone strength, a product of bone material and structural properties (bone size and architecture) either decreases (as in osteoporosis) or is exceeded (as in trauma). Progress in this field has become limited because the most advanced clinical tool for bone, dual energy x-ray absorptiometry (DXA), does not assess bone geometry and structure, important contributors to bone strength. However, the needed bone geometry information can be acquired by magnetic resonance imaging (MRI) and software algorithms applied to DXA data. Research plan. Two experiments will be conducted to 1) establish the in vivo accuracy of magnetic resonance imaging (MRI) and DXA for assessing bone geometry and bending strength and 2) determine the effect of adolescent physical activity on young adult bone geometry using two novel techniques (MRI and DXA structure analysis). Didactic Training. The educational program will be overseen by 3 co-mentors: Tim Mosher, M.D., will be responsible for all aspects related to MRI: Tom Beck, ScD, will be responsible for all aspects related to DXA-derived structural analyses; and Tom Lloyd, Ph.D., will be responsible for all aspects related to protection of human subjects, data analysis, manuscript and grant preparation. Anticipated results. The proposed research and educational program will establish new methods for measuring bone geometry, contribute to our understanding of the role of exercise during childhood on adult bone strength, and enable the candidate to establish an independent research program using novel methods of assessing bone geometry and muscle mass.