Bone Strength: Measurment and Clinical Applications

描述（由申请人提供）： 申请人的主要职业目标是阐明运动对青春期和青年期骨强度发展的作用。当骨强度降低（如骨质疏松症）或超过（如创伤）时，就会发生骨折，骨强度是骨材料和结构特性（骨大小和结构）的产物。由于最先进的骨临床工具双能X线吸收测定法（DXA）不能评估骨几何形状和结构（骨强度的重要贡献者），因此该领域的进展受到限制。然而，所需的骨骼几何形状信息可以通过磁共振成像（MRI）和应用于DXA数据的软件算法来获取。研究计划。将进行两项实验，以1）确定磁共振成像（MRI）和DXA评估骨几何形状和弯曲强度的体内准确性，2）使用两种新技术（MRI和DXA结构分析）确定青少年体力活动对年轻成人骨几何形状的影响。教学训练。教育计划将由3名共同导师监督：蒂姆·莫舍，医学博士，负责MRI相关的所有方面：Tom Beck，ScD，负责DXA衍生结构分析相关的所有方面; Tom Lloyd，Ph.D.，将负责与人类受试者保护、数据分析、手稿和资助准备相关的各个方面。预期结果。拟议的研究和教育计划将建立测量骨骼几何形状的新方法，有助于我们了解儿童时期锻炼对成人骨骼强度的作用，并使候选人能够使用评估骨骼几何形状和肌肉质量的新方法建立独立的研究计划。

DESCRIPTION (provided by applicant): The major career goals of the applicant are to elucidate the role of exercise on the development of bone strength during adolescence and young adulthood. Fractures occur when bone strength, a product of bone material and structural properties (bone size and architecture) either decreases (as in osteoporosis) or is exceeded (as in trauma). Progress in this field has become limited because the most advanced clinical tool for bone, dual energy x-ray absorptiometry (DXA), does not assess bone geometry and structure, important contributors to bone strength. However, the needed bone geometry information can be acquired by magnetic resonance imaging (MRI) and software algorithms applied to DXA data. Research plan. Two experiments will be conducted to 1) establish the in vivo accuracy of magnetic resonance imaging (MRI) and DXA for assessing bone geometry and bending strength and 2) determine the effect of adolescent physical activity on young adult bone geometry using two novel techniques (MRI and DXA structure analysis). Didactic Training. The educational program will be overseen by 3 co-mentors: Tim Mosher, M.D., will be responsible for all aspects related to MRI: Tom Beck, ScD, will be responsible for all aspects related to DXA-derived structural analyses; and Tom Lloyd, Ph.D., will be responsible for all aspects related to protection of human subjects, data analysis, manuscript and grant preparation. Anticipated results. The proposed research and educational program will establish new methods for measuring bone geometry, contribute to our understanding of the role of exercise during childhood on adult bone strength, and enable the candidate to establish an independent research program using novel methods of assessing bone geometry and muscle mass.