Systematic identification of Candida albicans secreted proteins required for virulence

系统鉴定白色念珠菌毒力所需的分泌蛋白

• 批准号: 2399029
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2399029
• 关键词: Systematic; identification; Candida; albicans; secreted

Candida albicans is the major fungal pathogen of people. It causes infections such as thrush, an irritating infection of the vagina or mouth, with vaginal infections affecting over three quarters of women at least once in their lifetime. It can also cause life-threatening bloodstream infections in a variety of hospital patients. These infections are difficult to diagnose and, even with treatment, the mortality rates are unacceptably high. A striking feature of C. albicans is its ability to release proteins that cause tissue damage and prevent the infection from being cleared. However, from our own work, it is clear that relatively few of the proteins C. albicans is predicted to release have been studied. In this project we will carry out an analysis of the full repitoire of proteins that C. albicans can actively release and determine their role in causing disease. Ultimately, in addition to increasing our knowledge of this important pathogen, this work will reveal new markers that could be used in the diagnosis of C. albicans infections. Furthermore, through this work we will identify targets for the development of new drugs or vaccines to help treat and prevent these diseases.

白色念珠菌是人类的主要致病真菌。它会引起鹅口疮等感染，这是一种刺激性的阴道或口腔感染，超过四分之三的妇女一生中至少有一次阴道感染。它还可以在各种医院患者中引起危及生命的血流感染。这些感染很难诊断，即使得到治疗，死亡率也高得令人无法接受。C.白色念珠菌的一个重要特征是它能够释放蛋白质，导致组织损伤并阻止感染被清除。然而，从我们自己的工作中，很明显，相对较少的蛋白质C。白色念珠菌的预测释放已经进行了研究。在这个项目中，我们将对C。白色念珠菌可以主动释放和确定它们在引起疾病中的作用。最终，除了增加我们对这种重要病原体的了解外，这项工作还将揭示可用于诊断C。白色念珠菌感染此外，通过这项工作，我们将确定开发新药或疫苗的目标，以帮助治疗和预防这些疾病。