Rapid POC diagnostic for Candida species and multidrug resistance identification

念珠菌属快速 POC 诊断和多重耐药性鉴定

• 批准号: 9907166
• 负责人: Hua Wise
• 金额: $ 22.48万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907166
• 关键词: Rapid; POC; diagnostic; Candida; species

PROJECT SUMMARY Invasive candidiasis is a serious and widely recognized fungal infection caused by Candida species. Antifungal resistance is a particular problem with Candida infections. Multidrug-resistant Candida infections have very few remaining treatment options. The type and level of drug resistance is unknown until the causative Candida species is determined via culture methods. A rapid diagnostic test to both identify Candida species and its antifungal drug resistance would help provide timely, appropriate treatment and reduce the spread of these resistant organisms. In response to a research topic that is specified by CDC for a culture-independent platform technology for Candida diagnosis and resistance identification for point-of-care/ low-resource settings, Lynntech proposes to develop a rapid, inexpensive, specific, and sensitive diagnostic that enables point-of-care Candida species and multidrug resistance identification without the need to rely on culture results. The innovation of our diagnostic test is effectively bringing highly sensitive molecular testing to point-of-care. Lynntech’s diagnostic test could potentially represent a significant new paradigm in point-of-care diagnosis to guide accurate therapy for Candida infections and help maximize positive patient outcomes.

项目总结