Detection and identification of Candida species in oral mucosal lesions for new oral care treatment

口腔粘膜病变中念珠菌属的检测和鉴定，用于新型口腔护理治疗

• 批准号: 21659483
• 负责人: SASANO Takashi
• 金额: $ 2.14万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659483/
• 关键词: カンジダ菌種; 口腔粘膜疾患; 口腔ケア; 口腔扁平苔癬; 真菌培養; シェーグレン症候群; 培養検査; 口腔カンジダ; 頭頸部癌放射線治療患者

Candida species were detected and identified in samples from the buccal mucosa, dorsal surface of the tongue and supragingival plaque of subjects with oral lichen planus(OLP). The Candida in the samples were cultured on selection agars, and identified by sequence analyses of 18S, 5. 8S and 25/28S rRNA. The isolation frequency of Candida was higher in subjects with OLP than in those with healthy oralmucosa. Non-C. albicans were only isolated from people with OLP. These results support the notion that subjects with OLP are more likely to have oral colonization with Candida, and that non-C. albicans are specifically present in subjects with this condition.

对口腔扁平苔藓(OLP)患者的口腔黏膜、舌背及龈上菌斑标本进行了念珠菌的检测和鉴定。将样品中的念珠菌培养在筛选的琼脂糖凝胶上，通过18S、5.8S和25/28S rRNA的序列分析进行鉴定。口腔扁平苔藓患者的念珠菌分离率高于健康口腔黏膜患者。非C类。白念珠菌只从口腔扁平苔藓患者身上分离出来。这些结果支持口腔扁平苔藓患者更有可能有口腔假丝酵母菌定植的观点，而非C。白念珠菌专门存在于患有这种疾病的受试者中。

项目成果

Detection and identification of non-Candida alblcans species in human oral lichen planus.

人口腔扁平苔藓中非白色念珠菌的检测和鉴定。

• 发表时间: 2011
• 期刊: Microbiol Immunol
• 影响因子: 2.6
• 作者: Mika Masaki;Takuichi Sato;Yumiko Sugawara;Takashi Sasano;Nobuhiro Takahashi.
• 通讯作者: Nobuhiro Takahashi.

Detection and identification of non-Candida albicans species in human oral lichen planus

• DOI: 10.1111/j.1348-0421.2010.00285.x
• 发表时间: 2011-01-01
• 期刊: MICROBIOLOGY AND IMMUNOLOGY
• 影响因子: 2.6
• 作者: Masaki, Mika;Sato, Takuichi;Takahashi, Nobuhiro
• 通讯作者: Takahashi, Nobuhiro

頭頸部癌放射線治療患者における口腔カンジダ菌の解析による口腔ケアの評価

头颈癌放疗患者口腔念珠菌分析评价口腔护理

• 发表时间: 2010
• 作者: 斎藤美紀子;菅原由美子;笹野高嗣;勝良剛詞;林孝文
• 通讯作者: 林孝文