Activity Gait and Efficacy (AGE) in Order Women

女性的活动步态和功效 (AGE)

• 批准号: 6726635
• 负责人: Edward McAuley
• 金额: $ 3.6万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6726635
• 关键词: Activity; Gait; Efficacy; AGE; Order

DESCRIPTION (provided by applicant): Osteoporosis is a major public health issue. Being African-American affords some protection from osteoporotic fracture primarily due to bone dependent factors such as a higher bone mass, density and shorter hip axis length; however, pilot data from our laboratory also suggests a racial difference in bone independent fracture risk factors including gait, balance and social cognitive factors such as fear of falling. However, to our knowledge, no research has studied the interrelationship between bone dependent and independent fracture risk factors in an older racially diverse sample of postmenopausal women. Additionally, little research has prospectively examined the relation between and among bone dependent and independent risk factors in black and white postmenopausal women. This is important work because black women are among the fastest growing segment of the population and alarming evidence suggests that although fewer black women sustain osteoporotic fractures, they have nearly a three-times greater likelihood of death due to complications from hip fracture. Thus, the primary purpose of this prospective study is to combine physiological bone health outcomes (bone mass, density and ultrasound attenuation), physical activity patterns, and balance and gait abilities with social cognitive outcomes including self-efficacy and expectations, to further elucidate the causes of this racial discrepancy in fracture rate. Secondarily, racial differences in body composition determinants (i.e. fat and fat-free mass) of bone health will be explored at baseline and in a prospective fashion. Per the parent grant design (1R01AG020118-01A1), a large sample of older (60 - 80 yrs) white (N = 150) and black (N = 150) women will be recruited with outcomes assessed at baseline, 1 year and 2 years. Bone and body composition will be assessed by dual energy X-ray absorptiometry (DXA). Additionally, quantitative ultrasound (QUS) will be used as an index of bone quality. This research has high public health priority because bone dependent and independent factors that influence the risk of osteoporotic fracture risk must be understood to implement effective programs for public health agendas and programs, specifically with regards to racial differences thereby optimizing programming for all individuals.

描述（由申请人提供）：骨质疏松症是一个主要的公共卫生问题。作为非裔美国人提供了一些保护，主要是由于骨依赖性因素，如较高的骨量，密度和较短的髋关节轴长度，从我们的实验室的试点数据也表明，在骨独立骨折的风险因素，包括步态，平衡和社会认知因素，如害怕跌倒的种族差异。然而，据我们所知，还没有研究在年龄较大的绝经后妇女的不同种族样本中研究骨依赖性和独立性骨折风险因素之间的相互关系。此外，很少有研究前瞻性地研究黑人和白色绝经后妇女骨依赖性和独立性危险因素之间的关系。这是一项重要的工作，因为黑人妇女是人口中增长最快的部分之一，令人震惊的证据表明，尽管黑人妇女较少遭受髋部骨折，但由于髋部骨折并发症而死亡的可能性几乎是三倍。因此，本前瞻性研究的主要目的是将联合收割机生理骨健康结局（骨量、密度和超声衰减）、体力活动模式、平衡和步态能力与社会认知结局（包括自我效能和期望）相结合，以进一步阐明骨折率种族差异的原因。其次，将在基线时和以前瞻性方式探索骨骼健康的身体组成决定因素（即脂肪和无脂肪质量）的种族差异。根据父母补助设计（1 R 01 AG 020118 - 01 A1），将招募老年（60 - 80岁）白色（N = 150）和黑人（N = 150）女性的大样本，并在基线、1年和2年时评估结局。将通过双能X线吸收测定法（DXA）评估骨和身体成分。此外，定量超声（QUS）将用作骨质指标。这项研究具有高度的公共卫生优先权，因为必须了解影响骨质疏松性骨折风险的骨依赖性和独立因素，以实施有效的公共卫生议程和计划，特别是关于种族差异，从而优化所有个人的规划。