Integrating Aging and Cancer Research

产品说明：（申请人的描述）这是一项计划和发展（P20）资助提案，旨在为爱荷华州大学（UI）霍尔顿综合癌症中心（HCCC）的研究活动增加一个癌症和衰老发展项目（CAP）。 虽然所有活动都将在HCCC内进行，但这是该中心与UI老龄问题中心共同努力的结果，也是两个中心建立良好的战略规划过程的结果。 基于这一过程，选择了建立在现有机构实力和需求基础上的三个科学主题与CAP一起开发：1）衰老和癌症的生物学[自由基生物学]; 2）合并症[合并症对临床癌症结局的影响];和3）治疗疗效和耐受性[老年癌症患者的化疗药理学]。 资金将专门用于战略规划过程确定的两个核心设施：1）一个数据库核心，为老年癌症患者的合并症和其他流行病学调查的原始研究提供保健分析数据; 2）扩大药效学和动力学研究的分析实验室能力。 此外，我们建议提供一些资金，以协助两个有针对性的教师招聘有关选定的主题：在卫生服务流行病学（共病主题）和医学肿瘤学/药理学（癌症治疗主题）。 其余的活动包括计划管理，包括正在进行的规划和评估活动，并提供不同规模的试点赠款，以促进选定的发展领域的研究。

DESCRIPTION: (Applicant's Description) This is a planning and development (P20) grant proposal to add a Developing Program in Cancer and Aging (CAP) to the research activities of the University of Iowa (UI) Holden Comprehensive Cancer Center (HCCC). While all activities will take place within the HCCC, this is the product of a joint effort of that center with the UI Center on Aging, and results from a well-established strategic planning process from both centers. Based on that process, three scientific themes that build on existing institutional strength and needs have been chosen for development with the CAP: 1) Biology of aging and cancer [free radical biology]; 2) Co-morbidity [Effects of co-morbidity on clinical cancer outcomes]; and 3) Treatment efficacy and tolerance [chemotherapy pharmacology in older cancer patients]. Funds will be devoted to two core facilities identified by the strategic planning process: 1) a database core for providing health care analytical data for original studies of co-morbidity and other epidemiological investigations of older cancer patients; and 2) expanding analytical laboratory capacity for pharmaco-dynamic and -kinetic studies. In addition, we propose providing some funds for assisting in two targeted faculty recruitments related to chosen themes: in health services epidemiology (co-morbidity theme) and medical oncology/pharmacology (cancer therapeutics theme). Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development.