Integrating Aging and Cancer Research

（申请人描述）这是一份规划和发展（P20）拨款提案，旨在为爱荷华大学（UI）霍尔顿综合癌症中心（HCCC）的研究活动增加一个癌症和衰老发展项目（CAP）。虽然所有的活动都将在HCCC内进行，但这是该中心与UI老龄化中心共同努力的产物，也是两个中心完善的战略规划过程的结果。基于这一过程，CAP选择了三个基于现有机构实力和需求的科学主题进行发展：1)衰老和癌症生物学[自由基生物学]；2)共发病[共发病对临床肿瘤结局的影响]；3)老年肿瘤患者的治疗疗效及耐受性[化疗药理学]。资金将用于战略规划进程确定的两个核心设施：1)数据库核心，为老年癌症患者合并症的原始研究和其他流行病学调查提供保健分析数据；2)扩大药效学和动力学研究的分析实验室能力。此外，我们建议提供一些资金，以协助与选定主题有关的两个有针对性的教员招聘：卫生服务流行病学（共同发病率主题）和医学肿瘤学/药理学（癌症治疗主题）。其余的活动包括方案管理，包括正在进行的规划和评价活动，以及提供不同规模的试点赠款，以促进选定的发展领域的研究。

DESCRIPTION: (Applicant's Description) This is a planning and development (P20) grant proposal to add a Developing Program in Cancer and Aging (CAP) to the research activities of the University of Iowa (UI) Holden Comprehensive Cancer Center (HCCC). While all activities will take place within the HCCC, this is the product of a joint effort of that center with the UI Center on Aging, and results from a well-established strategic planning process from both centers. Based on that process, three scientific themes that build on existing institutional strength and needs have been chosen for development with the CAP: 1) Biology of aging and cancer [free radical biology]; 2) Co-morbidity [Effects of co-morbidity on clinical cancer outcomes]; and 3) Treatment efficacy and tolerance [chemotherapy pharmacology in older cancer patients]. Funds will be devoted to two core facilities identified by the strategic planning process: 1) a database core for providing health care analytical data for original studies of co-morbidity and other epidemiological investigations of older cancer patients; and 2) expanding analytical laboratory capacity for pharmaco-dynamic and -kinetic studies. In addition, we propose providing some funds for assisting in two targeted faculty recruitments related to chosen themes: in health services epidemiology (co-morbidity theme) and medical oncology/pharmacology (cancer therapeutics theme). Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development.