Determinants of the secular increase in NHL

NHL 长期增加的决定因素

• 批准号: 6741144
• 负责人: Ellen Ting-Yee Chang
• 金额: $ 3.75万
• 依托单位: KAROLINSKA INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741144
• 关键词: Epstein Barr virus; Hodgkin' s disease; biopsy; cancer risk; disease /disorder etiology; enzyme linked immunosorbent assay; human T cell lymphotropic virus type 1; human tissue; immunoregulation; longitudinal human study; lymphocyte; neoplasm /cancer epidemiology; nonHodgkin' s lymphoma; oncogenic virus; polymerase chain reaction; postdoctoral investigator; questionnaires

DESCRIPTION (provided by applicant): The risk for malignant lymphoma (including non-Hodgkin's lymphoma, Hodgkin's disease, and chronic lymphocytic leukemias associated with immune modulation-- i.e., conditions and exposures that alter the immune system. Different subgroups lymphomas have different risk factors. Dr. Hans-OIov Adami and Dr. Mads Melbye are leading a population-based case-control study to investigate the etiology of lymphoma in Sweden and Denmark. A total of about 3,400 patients and 3,000 controls were recruited into the study between October 1999 and October 2002. Through a rapid case ascertainment system, the cases were identified shortly after diagnosis. The controls were randomly selected from national population registers and frequency-matched to the cases by sex and age. Both cases and controls have completed telephone-based questionnaires that elicited detailed information on exposures such as earlier medical conditions including infectious diseases, drug use and blood transfusions, UV light, and socio-economic factors and lifestyle. Blood samples were collected in order to assess the importance of viral exposures (EBV and HTLV-I). Tumor material from the cases has been reexamined and uniformly classified according to the REAL classification.

描述（由申请人提供）：恶性淋巴瘤（包括非霍奇金淋巴瘤、霍奇金病和与免疫调节相关的慢性淋巴细胞白血病-即，改变免疫系统的条件和暴露。不同亚群的淋巴瘤有不同的危险因素。Hans-Olov Adami博士和Mads Melbye博士正在瑞典和丹麦进行一项基于人群的病例对照研究，以调查淋巴瘤的病因。在1999年10月至2002年10月期间，共有约3,400名患者和3,000名对照者被招募参加这项研究。通过一个快速病例确认系统，这些病例在诊断后不久就被确认。对照组从国家人口登记册中随机选择，并按性别和年龄与病例频率匹配。病例组和对照组都完成了电话问卷，这些问卷收集了有关暴露的详细信息，如早期医疗状况，包括传染病、吸毒和输血、紫外线以及社会经济因素和生活方式。采集血样以评估病毒暴露（EBV和HTLV-I）的重要性。根据真实的分类，对病例的肿瘤材料进行了重新检查和统一分类。