Hodgkin Lymphoma Consortium: Pooling epidemiologic data for a research resource

霍奇金淋巴瘤联盟：汇集流行病学数据作为研究资源

• 批准号: 7591350
• 负责人: Ellen Ting-Yee Chang
• 金额: $ 7.25万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-17 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591350
• 关键词: Accounting; Address; Affect; Age; Area; Categories; Characteristics; Child; Clinical Management; Coupled; DNA; Data; Data Set; Databases; Dictionary; Disease; Employee Strikes; Epidemiologic Studies; Epidemiology; Etiology; Family; Family history of; Frequencies; Future; General Population; Genetic Predisposition to Disease; Goals; Heterogeneity; Histologic; Hodgkin Disease; Human Herpesvirus 4; Incidence; Individual; Intention; International; Internet; Interview; Investigation; Life; Lymph; Lymphoma; Malignant Neoplasms; Meta-Analysis; Modeling; Modification; Non-Hodgkin' s Lymphoma; Outcome; Patients; Policies; Primary Prevention; Procedures; Public Health; Questionnaires; Reporting; Research; Research Infrastructure; Resources; Risk; Risk Factors; Role; Sample Size; Specimen; Subcategory; Survival Rate; Testing; Ultraviolet Rays; Virus; cost; design; insight; member; neoplastic cell; novel; tumor; young adult

DESCRIPTION (provided by applicant): For Hodgkin lymphoma (HL), a common cancer of children and young adults, epidemiologic research has identified some risk factors, but the most important finding has been significant heterogeneity across patient and tumor characteristics (e.g., age, histologic subtype, tumor cell Epstein-Barr virus). Thus, the etiology of HL remains unclear, and in large part this is because its low incidence limits study sample sizes, particularly for the stratified analyses required addressing this heterogeneity. For the ultimate aim of primary prevention, additional studies of HL risk factors therefore are needed, but they must be very large. With the very efficient approach of combining existing HL epidemiologic data resources for collaborative re-analyses, we propose to form a consortium of HL studies within the NCI Inter Lymph consortium, pool data from these studies, and use the pooled dataset initially to test two novel hypotheses not addressable in individual studies. The study aims are to: 1) obtain and summarize descriptive information (data dictionaries, questionnaires, lists of data resources), and core demographic and tumor data for future analysis planning, from all participating HL studies; 2) post summarized study information and pooled core data frequencies on the Inter Lymph internet portal for reference for planning future analysis; 3) in the pooled dataset, test whether: a) ultraviolet light exposure is inversely related to HL risk; and b) HL cases with and without a family history of HL or lymphoma have differing risk factors suggesting environmental modification of genetic susceptibility. Leaders of 22 international HL studies have agreed to pool their resources (interview data, tumor specimens, and/or DNA on ~16,000 HL cases and 37,000 controls), following well-established and successful Inter Lymph policies and procedures. The pooled resource will be among the largest databases for study HL etiology ever compiled. Study strengths include: 1) producing a very powerful database for evaluating novel and extant risk factors within and across etiologically relevant subcategories of HL, for a level of insight about HL causes and outcomes not heretofore possible; 2) extremely efficient use of existing resources, with a large information gain for a relatively small cost; 3) efficient use of existing infrastructure in a successful international consortium of epidemiologic studies; 4) initial analyses in the pooled data in two promising areas: ultraviolet light exposure, a novel HL risk factor that is modifiable; and environmental modification of the well-described familial HL, with implications for etiology and clinical management of high-risk families.

描述(申请人提供)：霍奇金淋巴瘤(HL)是一种常见的儿童和年轻人癌症，流行病学研究已经确定了一些危险因素，但最重要的发现是患者和肿瘤特征(如年龄、组织亚型、肿瘤细胞爱泼斯坦-巴尔病毒)之间存在显著的异质性。因此，HL的病因仍不清楚，这在很大程度上是因为它的低发病率限制了研究样本量，特别是对于解决这种异质性所需的分层分析。为了达到初级预防的最终目的，因此需要对HL危险因素进行额外的研究，但这些研究的规模必须非常大。通过结合现有的HL流行病学数据资源进行协作性再分析的非常有效的方法，我们建议在NCI国际淋巴联盟内形成一个HL研究联盟，汇集这些研究的数据，并最初使用汇集的数据集来测试两个在个别研究中无法解决的新假设。这项研究的目的是：1)从所有参与的HL研究中获取和总结描述性信息(数据词典、问卷、数据资源列表)，以及用于未来分析规划的核心人口和肿瘤数据；2)发布总结研究信息，并在国际淋巴门户网站上汇集核心数据频率，以供未来分析参考；3)在汇集的数据集中，测试：a)紫外线暴露是否与HL风险呈负相关；以及b)有或无HL或淋巴瘤家族史的HL病例具有不同的风险因素，提示环境因素改变了遗传易感性。22项国际HL研究的带头人已经同意按照完善和成功的国际淋巴政策和程序，汇集他们的资源(采访数据、肿瘤标本和/或约16,000例HL病例和37,000例对照的DNA)。汇集的资源将是有史以来汇编的研究HL病因学的最大数据库之一。研究优势包括：1)创建一个非常强大的数据库，用于评估HL病因学相关亚类内和跨病因学相关亚类的新的和现有的风险因素，从而深入了解HL的病因和结果；2)非常有效地利用现有资源，以相对较小的成本获得大量信息；3)在成功的国际流行病学研究联盟中有效利用现有的基础设施；4)在两个有希望的领域对汇集的数据进行初步分析：紫外线暴露，一种可改变的新的HL风险因素；以及对描述良好的家族性HL进行环境改造，对高危家庭的病因学和临床治疗产生影响。