Determinants of the secular increase in NHL

描述(由申请人提供)：恶性淋巴瘤(包括非霍奇金淋巴瘤、霍奇金病和慢性淋巴细胞白血病)的风险与免疫调节有关--即改变免疫系统的条件和暴露。不同亚型的淋巴瘤有不同的危险因素。汉斯-奥伊奥夫·阿达米博士和马德斯·梅尔拜博士正在领导一项基于人群的病例对照研究，以调查瑞典和丹麦淋巴瘤的病因。在1999年10月至2002年10月期间，共有约3400名患者和3000名对照被纳入研究。通过一个快速病例确定系统，在诊断后不久就确定了病例。对照是从国家人口登记中随机选择的，并按性别和年龄与病例频率匹配。病例和对照组都完成了基于电话的问卷调查，获得了有关暴露的详细信息，例如早期的医疗条件，包括传染病、药物使用和输血、紫外线以及社会经济因素和生活方式。采集血样以评估病毒暴露(EBV和HTLV-I)的重要性。已对病例中的肿瘤材料进行了复查，并按真实分类进行了统一分类。

DESCRIPTION (provided by applicant): The risk for malignant lymphoma (including non-Hodgkin's lymphoma, Hodgkin's disease, and chronic lymphocytic leukemias associated with immune modulation-- i.e., conditions and exposures that alter the immune system. Different subgroups lymphomas have different risk factors. Dr. Hans-OIov Adami and Dr. Mads Melbye are leading a population-based case-control study to investigate the etiology of lymphoma in Sweden and Denmark. A total of about 3,400 patients and 3,000 controls were recruited into the study between October 1999 and October 2002. Through a rapid case ascertainment system, the cases were identified shortly after diagnosis. The controls were randomly selected from national population registers and frequency-matched to the cases by sex and age. Both cases and controls have completed telephone-based questionnaires that elicited detailed information on exposures such as earlier medical conditions including infectious diseases, drug use and blood transfusions, UV light, and socio-economic factors and lifestyle. Blood samples were collected in order to assess the importance of viral exposures (EBV and HTLV-I). Tumor material from the cases has been reexamined and uniformly classified according to the REAL classification.