Disinfectant Efficacy on Surface Bacteria and Biofilms

对表面细菌和生物膜的消毒效果

• 批准号: 6689932
• 负责人: BRETT Hugh James BAKER
• 金额: $ 10万
• 依托单位: MICROBION CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6689932
• 关键词: bacteria infection mechanism; biofilm; biomaterial development /preparation; bismuth; disinfectants; ethylenediaminetetraacetate; fluoride ion; nosocomial infection control; polyethylene glycols; scanning electron microscopy; surface coating; surface property; thiols; viscosity

DESCRIPTION (provided by applicant): This Small Business Innovation Research Grant Phase I project is investigating an innovative disinfectant product designed to improve on the limited efficacy of disinfectants used in hospitals. This research is based on the fact that inanimate surfaces in clinical environments frequently harbor viable, pathogenic, and often drug-resistant microorganisms. These surfaces are generally considered to be "non-critical" in the Spaulding Scheme, yet contamination of the clinical environment has been increasingly implicated in nosocomial infection in the recent scientific literature. Considering the mortality and morbidity associated with nosocomial infections, it is our assertion that in hospitals, there is no such thing as a "non-critical" surface. Our research is based on the hypothesis that disinfectant efficacy can be increased through a combination of innovative improvements specifically targeting current weaknesses in disinfectant formulation and methodology. Nosocomial microbes are often able to withstand conditions of drying, temperature variation, and protracted periods of time without nutritive support on a wide variety of inanimate clinical surfaces including sinks, water fountains, bed-rails, furniture, curtains, bathroom surfaces, telephone receivers, and many others. The capacity to adhere to surfaces contributes to the formation of biofilms (saturated and unsaturated), and to the transition to a more resistant phenotype. The capacity to adhere to inanimate surfaces, to gain resistance, and to form biofilms contributes to the ability of many microbial species to survive and remain endemic in clinical environments. Microbion Corporation has an innovative strategy to improve disinfectant efficacy in hospitals, and to more effectively prevent contact between compromised patients and pathogens. The strategic goals of this research are to improve 1) disinfectant efficacy, 2) disinfectant methodology, and 3) removal of adherent pathogenic microorganisms and biofilms from clinical environments. As commercial products, these innovative disinfectants are expected to help reduce the rate of nosocomial infection.

描述（由申请人提供）：该小型企业创新研究资助第一阶段项目正在研究一种创新消毒剂产品，旨在改善医院使用的消毒剂的有限功效。这项研究基于这样一个事实：临床环境中的无生命表面经常含有存活的、致病的且通常具有耐药性的微生物。这些表面在斯波尔丁方案中通常被认为是“非关键”的，但在最近的科学文献中，临床环境的污染越来越多地与医院感染有关。考虑到与医院感染相关的死亡率和发病率，我们断言，在医院中不存在“非关键”表面。我们的研究基于这样的假设：通过专门针对当前消毒剂配方和方法中的弱点的创新改进的组合可以提高消毒剂的功效。 医院微生物通常能够在各种无生命的临床表面（包括水槽、饮水机、床栏、家具、窗帘、浴室表面、电话听筒等）上承受干燥、温度变化和长时间没有营养支持的条件。粘附到表面的能力有助于生物膜（饱和和不饱和）的形成，并有助于向更具抵抗力的表型转变。粘附在无生命表面、获得抵抗力和形成生物膜的能力有助于许多微生物物种在临床环境中生存并保持流行的能力。 Microbion 公司拥有一项创新策略，旨在提高医院消毒剂的功效，并更有效地防止受损患者与病原体之间的接触。本研究的战略目标是提高 1) 消毒剂功效，2) 消毒剂方法，以及 3) 去除临床环境中粘附的病原微生物和生物膜。作为商业产品，这些创新消毒剂有望帮助降低医院感染率。