Supported Fluorous Lipids for Triphasic Reactions

用于三相反应的负载型氟脂质

• 批准号: 6582713
• 负责人: STEPHEN G. WEBER
• 金额: $ 15.24万
• 依托单位: FLUOROUS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-03 至 2006-02-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6582713
• 关键词: aluminum; chemical reaction; chemical synthesis; enzyme substrate; fluorine; lipids; nanotechnology; reagent /indicator; receptor

DESCRIPTION (provided by applicant): Long Term Objectives: To improve organic synthesis by combining product purification and chemical reaction steps. Specific Aims: Fluorous triphasic reactions accomplish chemical reaction and product purification in a single step. The idea is based on selective tagging of a reaction substrate with a fluorous tag to make it fluorosoluble. Substrate then can partition from a source (substrate) phase, through the central fluorous phase into a reaction (product) phase where a reaction occurs. The reaction detags the substrate, trapping it in the product phase. The tag is extracted into the fluorous phase. In practice, this attractive technology is hampered by the slow rate of product formation. Product is formed slowly because the volume of the fluorous phase is too large. The aims of the proposal are to increase the speed of fluorous triphasic reactions by developing novel supported liquid membrane formats and fluorous molecular carriers. Health Relatedness: Small molecule synthesis continues to be the dominant source of pharmaceuticals. The procedures described in this proposal will lead to purer synthetic products with less effort in comparison to normal practice.

描述（由申请人提供）：长期目标：通过结合产品纯化和化学反应步骤来改进有机合成。具体目的：氟三相反应一步完成化学反应和产物纯化。这个想法是基于用氟标签选择性标记反应底物，使其成为氟溶性的。然后，底物可以从源（底物）相通过中心氟相分配到反应（产物）相中，在反应（产物）相中发生反应。反应使底物脱粘，将其捕获在产物相中。标签被提取到氟相中。在实践中，这种有吸引力的技术受到产品形成速度缓慢的阻碍。由于氟相的体积太大，产物形成缓慢。该提案的目的是通过开发新型支撑液膜形式和氟分子载体来提高氟三相反应的速度。健康相关性：小分子合成仍然是药物的主要来源。与正常做法相比，本提案中描述的程序将导致更纯的合成产品，而且工作量更少。

项目成果

Transport of organic solutes through amorphous teflon AF films.

• DOI: 10.1021/ja052875p
• 发表时间: 2005-10
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Hong Zhao;Jie Zhang;N. Wu;Xu Zhang;K. Crowley;S. Weber