Core--Recruitment, epidemiology and biostatistics

该核心将通过扩大和维持未感染男性和女性的高风险队列、制定外展计划以招募更多患有急性或早期艾滋病毒感染的受试者以及促进跨多个地点的数据收集来支持本文提出的项目。该核心还将扩展纽约大学CFAR临床支持的功能 核心是为所有项目提供生物统计和流行病学分析。该中心将查明急性和早期艾滋病毒感染者，以支持及时完成每个项目。将积累每例受试者的流行病学信息，以估计HIV感染的日期和途径、人口统计学特征，以及可能时获得感染个体的信息，以获得自然史信息。急性和早期HIV感染的受试者将被推荐入组拟定的临床试验，并进行拟定的强化免疫学和病毒学研究，无论他们是否选择接受治疗。核心将为每个参与项目提供数据管理服务;创建快速向核心传输数据的方法，并与FSTRF一起为计划项目建立一个公共数据库。这将有助于分析合作研究者收集的观察结果之间的关联。核心工作人员将对计算机辅助访谈音频进行编程 该系统将用于以英语和法语收集队列参与者的人口统计学和行为信息。该中心将协助制定和审查方案项目中出现的新项目，并将为这些提案提供生物统计和流行病学方面的专门知识。

This core will support the projects proposed herein by the expansion and maintenance of the high risk cohort of uninfected men and women, the development of an outreach program to recruit additional subjects with acute or early HIV infection, and facilitation of data collection across multiple sites. This Core will also extend the functions of the NYU CFAR Clinical Support Core in the provision of biostatistical and epidemiological analyses for all projects. The Core will identify persons with acute and early HIV infection to support the timely completion of each of the projects. Epidemiologic information will be accumulated on each subject to estimate the date and route of HIV infection, demographic characteristics, and information when possible on the individual from whom infection was acquired in order to obtain information on natural history. Subjects with acute and early HIV infection will be referred for enrollment into the proposed clinical trial, and for intensive immunologic and virologic studies as proposed, whether or not they elect to be treated. The Core will provide data management services for each of the participating projects; create methods for the rapid transmission of data to the Core, and establish, in conjunction with FSTRF, a common data base for the program project. This will facilitate analysis of associations between the observations collected by the collaborating investigators. Core staff will program the audio computer assisted interviewing system to be used for collection of demographic and behavioral information from cohort participants in English and French. The Core will assist in the development and review of new projects emerging from the program project and will provide biostatistical and epidemiological expertise for these proposals.