Core--Recruitment, epidemiology and biostatistics

核心--招募、流行病学和生物统计学

• 批准号: 6808339
• 负责人: MICHAEL MARMOR
• 金额: $ 24.22万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808339
• 关键词: HIV infections; behavioral /social science research tag; biomedical facility; case history; clinical research; communicable disease transmission; health behavior; high risk behavior /lifestyle; human subject; interview; medical outreach /case finding; patient oriented research; statistics /biometry

This core will support the projects proposed herein by the expansion and maintenance of the high risk cohort of uninfected men and women, the development of an outreach program to recruit additional subjects with acute or early HIV infection, and facilitation of data collection across multiple sites. This Core will also extend the functions of the NYU CFAR Clinical Support Core in the provision of biostatistical and epidemiological analyses for all projects. The Core will identify persons with acute and early HIV infection to support the timely completion of each of the projects. Epidemiologic information will be accumulated on each subject to estimate the date and route of HIV infection, demographic characteristics, and information when possible on the individual from whom infection was acquired in order to obtain information on natural history. Subjects with acute and early HIV infection will be referred for enrollment into the proposed clinical trial, and for intensive immunologic and virologic studies as proposed, whether or not they elect to be treated. The Core will provide data management services for each of the participating projects; create methods for the rapid transmission of data to the Core, and establish, in conjunction with FSTRF, a common data base for the program project. This will facilitate analysis of associations between the observations collected by the collaborating investigators. Core staff will program the audio computer assisted interviewing system to be used for collection of demographic and behavioral information from cohort participants in English and French. The Core will assist in the development and review of new projects emerging from the program project and will provide biostatistical and epidemiological expertise for these proposals.

该核心将通过扩大和维持未感染男性和女性的高风险人群、制定外展计划来招募更多急性或早期艾滋病毒感染者以及促进跨多个地点的数据收集来支持本文提出的项目。该核心还将扩展纽约大学 CFAR 临床支持的功能 为所有项目提供生物统计和流行病学分析的核心。核心将识别急性和早期艾滋病毒感染者，以支持每个项目的及时完成。将积累每个受试者的流行病学信息，以估计艾滋病毒感染的日期和途径、人口统计特征，并在可能的情况下收集有关感染者的信息，以获得自然史信息。患有急性和早期艾滋病毒感染的受试者将被转介参加拟议的临床试验，并进行拟议的强化免疫学和病毒学研究，无论他们是否选择接受治疗。核心将为每个参与项目提供数据管理服务；创建将数据快速传输到核心的方法，并与 FSRF 一起建立该计划项目的通用数据库。这将有助于分析合作研究人员收集的观察结果之间的关联。核心人员将对音频计算机辅助访谈进行编程 系统用于收集英语和法语队列参与者的人口统计和行为信息。核心将协助开发和审查该计划项目中出现的新项目，并将为这些提案提供生物统计和流行病学专业知识。